Abstract

In this year, we conducted four sub-projects. First, we employed oxygen sensors coupled with high-speed amperometry to evaluate fluctuations in brain oxygen levels induced by morphine, an opioid analgesic drug frequently abused by humans. Second, we employed this technology to examine changes in brain oxygen induced by cocaine and the role of peripheral neural substrates in mediating these effects. Third, we examined how benzodiazepine drugs affect hypoxic effects of intravenous heroin. Finally, we examined the role of peripheral and central opioid receptors in mediating brain hypoxia induced by heroin.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADA000566-10
Application #
9995337
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Solis Jr, Ernesto; Afzal, Anum; Kiyatkin, Eugene A (2018) Changes in brain oxygen and glucose induced by oxycodone: Relationships with brain temperature and peripheral vascular tone. Neuropharmacology 133:481-490
Solis Jr, Ernesto; Bola, R Aaron; Fasulo, Bradley J et al. (2017) Brain Hyperglycemia Induced by Heroin: Association with Metabolic Neural Activation. ACS Chem Neurosci 8:265-271
Solis Jr, Ernesto; Cameron-Burr, Keaton T; Kiyatkin, Eugene A (2017) Heroin Contaminated with Fentanyl Dramatically Enhances Brain Hypoxia and Induces Brain Hypothermia. eNeuro 4:
Solis Jr, Ernesto; Cameron-Burr, Keaton T; Shaham, Yavin et al. (2017) Intravenous Heroin Induces Rapid Brain Hypoxia and Hyperglycemia that Precede Brain Metabolic Response. eNeuro 4:
Bola, R Aaron; Kiyatkin, Eugene A (2017) Brain temperature effects of intravenous heroin: State dependency, environmental modulation, and the effects of dose. Neuropharmacology 126:271-280
Solis, Ernesto; Cameron-Burr, Keaton T; Shaham, Yavin et al. (2017) Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature. Neuropsychopharmacology :
Solis Jr, Ernesto; Cameron-Burr, Keaton T; Kiyatkin, Eugene A (2017) Rapid Physiological Fluctuations in Nucleus Accumbens Oxygen Levels Induced by Arousing Stimuli: Relationships with Changes in Brain Glucose and Metabolic Neural Activation. Front Integr Neurosci 11:9
Bola, R Aaron; Kiyatkin, Eugene A (2016) Robust Brain Hyperglycemia during General Anesthesia: Relationships with Metabolic Brain Inhibition and Vasodilation. Front Physiol 7:39
Wakabayashi, Ken T; Spekterman, Laurence; Kiyatkin, Eugene A (2016) Experience-dependent escalation of glucose drinking and the development of glucose preference over fructose - association with glucose entry into the brain. Eur J Neurosci 43:1422-30
Wakabayashi, Ken T; Kiyatkin, Eugene A (2015) Central and peripheral contributions to dynamic changes in nucleus accumbens glucose induced by intravenous cocaine. Front Neurosci 9:42

Showing the most recent 10 out of 27 publications