Abstract

A major mission of this group involves the management and service functions of three NMR instrumentation provided to NIDDK scientists of the Laboratory of Bioorganic Chemistry, other NIH laboratories and, to a limited extent, to scientists of other institutes. Management and service include 1) plan, coordinate and supervise the relocation/installation of all NMR instruments in LBC, 2) troubleshooting and up-keeping NMR instruments, 3) provide technical assistance and offer data interpretation to investigators, 4) teach investigators the application of NMR technique to meet their research needs and 5) engage in collaborative research projects in support of organizational mission. All three spectrometers are connected to the NIDDK network allowing investigators performing data transmission remotely.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADK032101-14
Application #
8148733
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2010
Total Cost
$155,475
Indirect Cost

  Institution

Name
National Institute of Diabetes and Digestive and Kidney Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Yin, Qian; Abendschein, Dana; Muccigrosso, David et al. (2017) A non-contrast CMR index for assessing myocardial fibrosis. Magn Reson Imaging 42:69-73
Liu, Hong-Bing; Lauro, Gianluigi; O'Connor, Robert D et al. (2017) Tulongicin, an Antibacterial Tri-Indole Alkaloid from a Deep-Water Topsentia sp. Sponge. J Nat Prod 80:2556-2560
O'Connor, Robert D; Singh, Manmilan; Chang, James et al. (2017) Dual Mode of Action for Plusbacin A3 in Staphylococcus aureus. J Phys Chem B 121:1499-1505
Shahzad-Ul-Hussan, Syed; Sastry, Mallika; Lemmin, Thomas et al. (2017) Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins. Chembiochem 18:764-771
Rodríguez, David; Chakraborty, Saibal; Warnick, Eugene et al. (2016) Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor Agonists. ACS Chem Biol 11:2763-2772
Dogo-Isonagie, Cajetan; Lee, Su-Lin; Lohith, Katheryn et al. (2016) Design and synthesis of small molecule-sulfotyrosine mimetics that inhibit HIV-1 entry. Bioorg Med Chem 24:1718-28
Airhart, Sophia; Cade, W Todd; Jiang, Hui et al. (2016) A Diet Rich in Medium-Chain Fatty Acids Improves Systolic Function and Alters the Lipidomic Profile in Patients With Type 2 Diabetes: A Pilot Study. J Clin Endocrinol Metab 101:504-12
Liu, Hongbing; Lohith, Katheryn; Rosario, Margaret et al. (2016) Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity. J Nat Prod 79:1872-6
Tosh, Dilip K; Ciancetta, Antonella; Warnick, Eugene et al. (2016) Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists. J Med Chem 59:3249-63
Fang, Zhong-Ze; Tosh, Dilip K; Tanaka, Naoki et al. (2015) Metabolic mapping of A3 adenosine receptor agonist MRS5980. Biochem Pharmacol 97:215-23

Showing the most recent 10 out of 14 publications