Abstract

A major mission of this group involves the management and service of three NMR spectrometers that are used by NIH scientists, primarily but not exclusively those of the Laboratory of Bioorganic Chemistry, for the identification of natural and synthetic products, tertiary structure determination, binding assays, and molecular dynamics. Management and service include 1) troubleshooting and servicing NMR spectometers, 2) provide technical assistance and data interpretation, 3) teach investigators NMR techniques that can aid their research goals, and 4) engage in collaborative research projects in support of organizational missions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADK032101-22
Application #
10006690
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
22
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
National Institute of Diabetes and Digestive and Kidney Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

O'Connor, Robert D; Singh, Manmilan; Chang, James et al. (2017) Dual Mode of Action for Plusbacin A3 in Staphylococcus aureus. J Phys Chem B 121:1499-1505
Shahzad-Ul-Hussan, Syed; Sastry, Mallika; Lemmin, Thomas et al. (2017) Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins. Chembiochem 18:764-771
Yin, Qian; Abendschein, Dana; Muccigrosso, David et al. (2017) A non-contrast CMR index for assessing myocardial fibrosis. Magn Reson Imaging 42:69-73
Liu, Hong-Bing; Lauro, Gianluigi; O'Connor, Robert D et al. (2017) Tulongicin, an Antibacterial Tri-Indole Alkaloid from a Deep-Water Topsentia sp. Sponge. J Nat Prod 80:2556-2560
Rodríguez, David; Chakraborty, Saibal; Warnick, Eugene et al. (2016) Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor Agonists. ACS Chem Biol 11:2763-2772
Dogo-Isonagie, Cajetan; Lee, Su-Lin; Lohith, Katheryn et al. (2016) Design and synthesis of small molecule-sulfotyrosine mimetics that inhibit HIV-1 entry. Bioorg Med Chem 24:1718-28
Airhart, Sophia; Cade, W Todd; Jiang, Hui et al. (2016) A Diet Rich in Medium-Chain Fatty Acids Improves Systolic Function and Alters the Lipidomic Profile in Patients With Type 2 Diabetes: A Pilot Study. J Clin Endocrinol Metab 101:504-12
Liu, Hongbing; Lohith, Katheryn; Rosario, Margaret et al. (2016) Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity. J Nat Prod 79:1872-6
Tosh, Dilip K; Ciancetta, Antonella; Warnick, Eugene et al. (2016) Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists. J Med Chem 59:3249-63
Fang, Zhong-Ze; Tosh, Dilip K; Tanaka, Naoki et al. (2015) Metabolic mapping of A3 adenosine receptor agonist MRS5980. Biochem Pharmacol 97:215-23

Showing the most recent 10 out of 14 publications