Participant enrollment was completed for the first phase of this project in 9/2012, resulting in a sample of 117 military personnel seeking care for a sleep disorder. We elected to continue recruitment of participants and to develop a second phase to the study. The institutional review board approval of re-initiating this project was approved on 8/13/2013. All participants in this study underwent a polysomonographic sleep evlauation and had blood collected for biomarker measurement which includes proteomics, gene-expression and DNA methyltion. Participants are seen at baseline and then 6 weeks following this. We use follow-up data to examine changes in symptoms with standard of care interventions. Accomplishments include data-based publications as well as presentations by this group. These include the following: Publications: Gill, J.M., Lee, H., Saligan, L., Szanton, Women in recovery from PTSD have similar inflammation and quality of life as non-traumatized controls, Journal of Psychosomatic Research, Online Release December 2012 Mysliwiec V, Gill J, Lee H, Baxter T, Pierce R, Barr TL, Krakow B, Roth BJ, Sleep Disorders in U.S. Military Personnel: A High Rate of Comorbid Insomnia and Obstructive Sleep Apnea. CHEST, Online Release May 16, 2013. Gill, J. Lee H, Baxter T, Pierce R, Barr TL, Krakow B, Mysliwiec V. Adherence with CPAP in OSA Patients is Linked to Increases in IGF-1 and Reductions in Symptoms of PTSD. (Accepted Psychosomatic Medicine)

Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2013
Total Cost
$742,562
Indirect Cost
Name
National Institute of Nursing Research
Department
Type
DUNS #
City
State
Country
Zip Code
Osier, Nicole; Motamedi, Vida; Edwards, Katie et al. (2018) Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment. Mol Neurobiol :
Motamedi, Vida; Kanefsky, Rebekah; Matsangas, Panagiotis et al. (2018) Elevated tau and interleukin-6 concentrations in adults with obstructive sleep apnea. Sleep Med 43:71-76
Devoto, Christina; Arcurio, Lindsay; Fetta, Joseph et al. (2017) Inflammation Relates to Chronic Behavioral and Neurological Symptoms in Military Personnel with Traumatic Brain Injuries. Cell Transplant 26:1169-1177
Martin, Christiana G; Kim, Hyungsuk; Yun, Sijung et al. (2017) Circulating miRNA associated with posttraumatic stress disorder in a cohort of military combat veterans. Psychiatry Res 251:261-265
Cashion, Ann K; Gill, Jessica; Hawes, Rebecca et al. (2016) National Institutes of Health Symptom Science Model sheds light on patient symptoms. Nurs Outlook 64:499-506
Devoto, Christina; Arcurio, Lindsay; Fetta, Joseph et al. (2016) Inflammation Relates to Chronic Behavioral and Neurological Symptoms in Military with Traumatic Brain Injuries. Cell Transplant :
Livingston, Whitney S; Rusch, Heather L; Nersesian, Paula V et al. (2015) Improved Sleep in Military Personnel is Associated with Changes in the Expression of Inflammatory Genes and Improvement in Depression Symptoms. Front Psychiatry 6:59
Rusch, Heather L; Shvil, Erel; Szanton, Sarah L et al. (2015) Determinants of psychological resistance and recovery among women exposed to assaultive trauma. Brain Behav 5:e00322
Barr, Taura; Livingston, Whitney; Guardado, Pedro et al. (2015) Chapter 8 Military Personnel With Traumatic Brain Injuries and Insomnia Have Reductions in PTSD and Improved Perceived Health Following Sleep Restoration: A Relationship Moderated by Inflammation. Annu Rev Nurs Res 33:249-66
Rusch, Heather L; Guardado, Pedro; Baxter, Tristin et al. (2015) Improved Sleep Quality is Associated with Reductions in Depression and PTSD Arousal Symptoms and Increases in IGF-1 Concentrations. J Clin Sleep Med 11:615-23

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