Abstract

The Applied Molecular Pathology Laboratory (AMPL) has been in development during fiscal year 2010, with the hiring of two staff members, acquisition of capital equipment and development of standard operating procedures, with the initiation of studies to commence in FY 2011. During the start up phase, standard operating procedures for construction of tissue microarrays (TMAs), validated immunohistochemistry, and the isolation of RNA and DNA from formalin fixed paraffin embedded tissue have been developed. A digital image database has been implemented for the organization and collection of annotations and outputs of image analysis of digital pathology images.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICBC011257-05
Application #
8938474
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Jia, Jinping; Bosley, Allen D; Thompson, Abbey et al. (2014) CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells. Cancer Res 74:2785-95
Camargo, M Constanza; Kim, Woo-Ho; Chiaravalli, Anna Maria et al. (2014) Improved survival of gastric cancer with tumour Epstein-Barr virus positivity: an international pooled analysis. Gut 63:236-43
Horne, Hisani N; Sherman, Mark E; Garcia-Closas, Montserrat et al. (2014) Breast cancer susceptibility risk associations and heterogeneity by E-cadherin tumor tissue expression. Breast Cancer Res Treat 143:181-7
Li, Wen-Qing; Hu, Nan; Burton, Victoria H et al. (2014) PLCE1 mRNA and protein expression and survival of patients with esophageal squamous cell carcinoma and gastric adenocarcinoma. Cancer Epidemiol Biomarkers Prev 23:1579-1588
Kohaar, Indu; Porter-Gill, Patricia; Lenz, Petra et al. (2013) Genetic variant as a selection marker for anti-prostate stem cell antigen immunotherapy of bladder cancer. J Natl Cancer Inst 105:69-73
Yang, Xiaohong R; Figueroa, Jonine D; Hewitt, Stephen M et al. (2013) Estrogen receptor and progesterone receptor expression in normal terminal duct lobular units surrounding invasive breast cancer. Breast Cancer Res Treat 137:837-47
Wadt, Karin; Choi, Jiyeon; Chung, Joon-Yong et al. (2012) A cryptic BAP1 splice mutation in a family with uveal and cutaneous melanoma, and paraganglioma. Pigment Cell Melanoma Res 25:815-8
Yang, Xiaohong R; Figueroa, Jonine D; Falk, Roni T et al. (2012) Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers. Breast Cancer Res 14:R64
Lenz, Petra; Pfeiffer, Ruth; Baris, Dalsu et al. (2012) Cell-cycle control in urothelial carcinoma: large-scale tissue array analysis of tumor tissue from Maine and Vermont. Cancer Epidemiol Biomarkers Prev 21:1555-64
Gonzalez-Bosquet, Jesus; Calcei, Jacob; Wei, Jun S et al. (2011) Detection of somatic mutations by high-resolution DNA melting (HRM) analysis in multiple cancers. PLoS One 6:e14522

Showing the most recent 10 out of 13 publications