Abstract

The Animal MRI Core has performed MRI studies, data analysis, manuscript preparation input, and/or a manuscript was published on the following projects from Oct. 1, 2015 to Sept 30, 2016. Projects are listed alphabetically by Principal Investigator: 1. Arai, Andrew and Epstein, Steven (Washington Hospital Center), fellow Lipinski (Washington Hospital Center). Collaboration between Arai Lab, AMRI Core and Stephen Epstein. Imaging labeled liposomes in infarcted mouse myocardium. Meeting abstract in 2015, Paper published in 2016. 2. Chung, Jay, fellow Xu. NHLBI protocol H-0030R4. Dobutamine stress testing in a mouse model. 3. Collins, Francis, fellow Dubose. NHGRI protocol G03-5. Examination of aorta and pulmonary artery for possible patent ductus arteriosus in Lmna knock-in mice. 4. Finkel, Toren, fellows Ye and Zhu. NHLBI, protocol H-0083. Fellow Ye: Mouse model of pulmonary hypertension. Imaging is ongoing in 2016. Fellow Zhu: High resolution microimaging of mouse brain. 5. Gahl, William, NHGRI Protocol G04-3, Staff Scientist Malicdan. Cardiac function and anatomy in a cardiac hypertrophy mouse model. Meeting abstract in 2015, manuscript currently in progress. 6. Jagoda, Elaine, Green, Michael V, and Choyke, Peter. NCI protocol MIP-006. Correlation of rat left ventricular volume from MRI to that obtained by an experimental PET procedure. 7. Moss, Joel, NHLBI. Darling, Thomas, Dept. of Dermatology, USUHS, fellow Klover (USUHS). NHLBI protocol H-0028. TS-2 tuberous sclerosis model mice, whole body imaging and data interpretation. The group has completed a manuscript in Feb 2016. 8. Ottinger, Elizabeth. Therapeutics for Rare and Neglected Diseases (TRND), NCATS. Protocols NCI 14-103 and NHLBI H-0219. Efficacy study for treatment of cardiac hypertrophy in LEOPARD syndrome model mice. 9. Sack, Michael, Staff Scientist Han. NHLBI protocol H-0222- Imaging studies concentrating on a Parkin model with TAC surgery (aortic banding). A manuscript is currently under review. 10. Segars, James, NICHD protocol 15-060. Fellow Baig-Ward. Cardiac function and dobutamine stress testing on Brx (AKAP 13) model. Completed imaging in 2015, analysis continuing in 2016.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICHL005909-09
Application #
9353168
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
U.S. National Heart Lung and Blood Inst
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Klover, Peter J; Thangapazham, Rajesh L; Kato, Jiro et al. (2017) Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3. Elife 6:
Han, Kim; Hassanzadeh, Shahin; Singh, Komudi et al. (2017) Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress. Sci Rep 7:2093
Lipinski, Michael J; Albelda, M Teresa; Frias, Juan C et al. (2016) Multimodality imaging demonstrates trafficking of liposomes preferentially to ischemic myocardium. Cardiovasc Revasc Med 17:106-12
Tian, E; Stevens, Sharon R; Guan, Yu et al. (2015) Galnt1 is required for normal heart valve development and cardiac function. PLoS One 10:e0115861
Furusawa, Takashi; Rochman, Mark; Taher, Leila et al. (2015) Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness. Nat Commun 6:6138
van der Pals, Jesper; Hammer-Hansen, Sophia; Nielles-Vallespin, Sonia et al. (2015) Temporal and spatial characteristics of the area at risk investigated using computed tomography and T1-weighted magnetic resonance imaging. Eur Heart J Cardiovasc Imaging 16:1232-40
Beliveau, Pascale; Cheriet, Farida; Anderson, Stasia A et al. (2015) Quantitative assessment of myocardial fibrosis in an age-related rat model by ex vivo late gadolinium enhancement magnetic resonance imaging with histopathological correlation. Comput Biol Med 65:103-13
Wan, Wuzhou; Liu, Qian; Lionakis, Michail S et al. (2015) Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice. Cardiovasc Res 106:478-87
Holmström, Kira M; Pan, Xin; Liu, Julia C et al. (2015) Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter. J Mol Cell Cardiol 85:178-82
Song, Minjung; San, Hong; Anderson, Stasia A et al. (2014) Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria. Stem Cell Res Ther 5:41

Showing the most recent 10 out of 21 publications