Animal MRI/Imaging Core

Anderson, Stasia

Abstract

The Animal MRI Core has performed MRI studies, data analysis, manuscript preparation input, and/or a manuscript was published on the following projects from Oct. 1, 2016 to Sept 30, 2017. Projects are listed alphabetically by Principal Investigator: 1. Elinoff, Jason (CC). Pulmonary hypertension models, including Rat hypoxia/normoxia and murine CAV-1 KO; function, RV wall, ventricular volumes, RA dimension and LV eccentricity index. Two abstracts presented at American Thioracic Society meeting, 2017. 2. Finkel, Toren, fellows Sun and Liu. NHLBI, protocol H-0083. Fellow Sun: Mouse model of pulmonary hypertension. Imaging is ongoing in 2016. Fellow Liu: Cardiac function and strain. 3. Kozel, Beth: Fellow Levin, Flow mapping of coronary sinus, cardiac function and strain in a mouse model with diminished coronary flow reserve. 4. Liu, Chengyu (NHLBI): Imaging therapeutic device placement and cardiac function in a mouse myocardial infarction model with cellular therapy. 5. Moss, Joel, NHLBI. Darling, Thomas, Dept. of Dermatology, USUHS, fellow Klover (USUHS). NHLBI protocol H-0028. TS-2 tuberous sclerosis model mice, whole body imaging and data interpretation. Manuscript published in 2017. 6. Ottinger, Elizabeth. Therapeutics for Rare and Neglected Diseases (TRND), NCATS. Protocols NCI 14-103 and NHLBI H-0219. Efficacy study for treatment of cardiac hypertrophy in LEOPARD syndrome model mice. Completed in 2017. 7. Rusan, fellow Schoborg. Microimaging drosophila at 14T. 8. Sack, Michael, Staff Scientist Han. NHLBI protocol H-0222- Imaging studies concentrating on a Parkin model with TAC surgery (aortic banding). Manuscript published in 2017.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Scientific Cores Intramural Research (ZIC)
• Project #: 1ZICHL005909-10
• Application #: 9551945
• Support Year: 10
• Fiscal Year: 2017

Institution

• Name: U.S. National Heart Lung and Blood Inst

Publications

Klover, Peter J; Thangapazham, Rajesh L; Kato, Jiro et al. (2017) Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3. Elife 6:

Han, Kim; Hassanzadeh, Shahin; Singh, Komudi et al. (2017) Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress. Sci Rep 7:2093

Lipinski, Michael J; Albelda, M Teresa; Frias, Juan C et al. (2016) Multimodality imaging demonstrates trafficking of liposomes preferentially to ischemic myocardium. Cardiovasc Revasc Med 17:106-12

Tian, E; Stevens, Sharon R; Guan, Yu et al. (2015) Galnt1 is required for normal heart valve development and cardiac function. PLoS One 10:e0115861

Furusawa, Takashi; Rochman, Mark; Taher, Leila et al. (2015) Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness. Nat Commun 6:6138

van der Pals, Jesper; Hammer-Hansen, Sophia; Nielles-Vallespin, Sonia et al. (2015) Temporal and spatial characteristics of the area at risk investigated using computed tomography and T1-weighted magnetic resonance imaging. Eur Heart J Cardiovasc Imaging 16:1232-40

Beliveau, Pascale; Cheriet, Farida; Anderson, Stasia A et al. (2015) Quantitative assessment of myocardial fibrosis in an age-related rat model by ex vivo late gadolinium enhancement magnetic resonance imaging with histopathological correlation. Comput Biol Med 65:103-13

Wan, Wuzhou; Liu, Qian; Lionakis, Michail S et al. (2015) Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice. Cardiovasc Res 106:478-87

Holmström, Kira M; Pan, Xin; Liu, Julia C et al. (2015) Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter. J Mol Cell Cardiol 85:178-82

Song, Minjung; San, Hong; Anderson, Stasia A et al. (2014) Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria. Stem Cell Res Ther 5:41