The PLCO Trial was designed as a large-scale randomized trial to investigate whether selected screening tests for cancers of the prostate, lung, colon, and ovaries lead to a reduction in mortality from these cancers. Approximately 155,000 women and men aged 55 to74 were enrolled in PLCO between 1992 and 2001. Participants were randomized into two arms, with intervention-arm participants receiving a series of six annual examinations to screen for prostate cancer, lung cancer, colorectal cancer, and ovarian cancer, and comparison-arm participants receiving routine health care from their health providers. Participants completed a risk factor questionnaire at baseline and a supplemental questionnaire in 2006. Another questionnaire (the Medical Use Questionnaire), designed to collect information on basic lifestyle factors and medication use, was mailed to PLCO participants in the first half of 2013. Questionnaires were completed and returned by approximately 56,000 participants. The questionnaires were designed to allow data entry using electronic scanning methods and character recognition software. The participant responses have been computerized and are currently undergoing data entry quality control checks at the PLCO Central Data Collection Center

Public Health Relevance

There is a lack of research on commonly used medications in relation to cancer incidence and major causes of cancer mortality in the elderly population. As PLCO participants now range from 74-94 years of age, we collected additional information on medications that are particularly common among older adults including those that have not been assessed in PLCO previously. The questions were designed to determine the number of current users of common medications and to solicit further details on the number, frequency and/or duration of medication use in current users. These data will be used to investigate potential associations between commonly used medications and cancer risk in the elderly. We also collected updated data on smoking status and current weight.

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
261201300008I-0-26100004-1
Application #
8764982
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$113,180
Indirect Cost
Name
Information Management Services, Inc.
Department
Type
DUNS #
083656892
City
Calverton
State
MD
Country
United States
Zip Code
20705