Eighty to ninety percent of what most young children learn about the world comes through vision. The same cannot be said when we seek to learn about the inner workings of our own body, because light beyond """"""""""""""""skin deep"""""""""""""""" becomes diffused due to multiple scattering. Instead, researchers have resorted to alternative means-such as X-ray, magnetic resonance, and ultrasound-to probe deep into the body. Until now, most advances in optical imaging have been geared towards high-resolution functional and molecular imaging at depths less than 1 mm in scattering tissue. The pursuit of deep-tissue optical imaging with high spatial resolution has been stymied by the inherent optical diffusion-the grand challenge since the inception of biomedical optics. We must meet this challenge to reach the full potential of light because it is such a powerful tool from both the physical and biological perspectives. Physically, the tiny fraction of the electromagnetic spectrum that light covers is the only part that probes molecular structures directly;biologically, the ability of molecules to sense, react to, and emit light is encoded on the most fundamental (i.e., genetic) level! In addition, light as nonionizing radiation is as safe to biological organisms as air and water. Therefore, light is the most natural choice fo visualizing biological structures and events, interrogating and controlling biological processes, as well as diagnosing and treating diseases, if only we could overcome the optical diffusion-a seemingly unbreakable barrier. While multiple scattering of light is treated as a problem in conventional wisdom, I believe that it should be part of the solution. Our recent work on time-reversed ultrasonically encoded (TRUE) optical focusing (Nature Photonics 2011) is a first breakthrough in this direction. TRUE focusing can noninvasively deliver light to a dynamically defined focus deep in a scattering medium. This invention opens the door to an even greater paradigm-shifti

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
NIH Director’s Pioneer Award (NDPA) (DP1)
Project #
5DP1EB016986-02
Application #
8543732
Study Section
Special Emphasis Panel (ZGM1-NDPA-A (01))
Program Officer
Conroy, Richard
Project Start
2012-09-30
Project End
2017-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
2
Fiscal Year
2013
Total Cost
$737,200
Indirect Cost
$252,200
Name
Washington University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Yang, Jiamiao; Shen, Yuecheng; Liu, Yan et al. (2017) Focusing light through scattering media by polarization modulation based generalized digital optical phase conjugation. Appl Phys Lett 111:201108
Lin, Li; Zhang, Pengfei; Xu, Song et al. (2017) Handheld optical-resolution photoacoustic microscopy. J Biomed Opt 22:41002
Hemphill, Ashton S; Shen, Yuecheng; Liu, Yan et al. (2017) High-speed single-shot optical focusing through dynamic scattering media with full-phase wavefront shaping. Appl Phys Lett 111:221109
Li, Lei; Zhu, Liren; Ma, Cheng et al. (2017) Single-impulse Panoramic Photoacoustic Computed Tomography of Small-animal Whole-body Dynamics at High Spatiotemporal Resolution. Nat Biomed Eng 1:
Yang, Jiamiao; Gong, Lei; Xu, Xiao et al. (2017) Motionless volumetric photoacoustic microscopy with spatially invariant resolution. Nat Commun 8:780
Wong, Terence T W; Zhang, Ruiying; Hai, Pengfei et al. (2017) Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy. Sci Adv 3:e1602168
Wong, Terence T W; Zhang, Ruiying; Zhang, Chi et al. (2017) Label-free automated three-dimensional imaging of whole organs by microtomy-assisted photoacoustic microscopy. Nat Commun 8:1386
Cerdà-Ibáñez, M; Pérez-Torregrosa, V T; Olate-Pérez, A et al. (2017) Qualitative analysis of repaired filtering blebs with anterior segment-optical coherence tomography. Arch Soc Esp Oftalmol 92:359-365
Shen, Yuecheng; Liu, Yan; Ma, Cheng et al. (2017) Sub-Nyquist sampling boosts targeted light transport through opaque scattering media. Optica 4:97-102
Wong, Terence T W; Zhou, Yong; Garcia-Uribe, Alejandro et al. (2017) Use of a single xenon flash lamp for photoacoustic computed tomography of multiple-centimeter-thick biological tissue ex vivo and a whole mouse body in vivo. J Biomed Opt 22:41003

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