Memory research in Alzheimer's disease (AD) has typically focused on word-based or verbal stimuli. However, pictures may have more clinical and ecological importance, as patients are commonly faced with visual stimuli, such as people, landmarks, and medications. Research has shown that pictures can help healthy older adults improve discrimination, reduce false memories, and shift to a more conservative response bias. Response bias is one's tendency to respond """"""""old"""""""" or """"""""new"""""""" on a recognition memory test. AD patients exhibit an abnormally high rate of false memories and a liberal response bias. Preliminary studies suggest that AD patients may also be able to use the distinctive information provided by pictures to improve their discrimination and reduce their number of false memories. The current application will use techniques of experimental psychology and cognitive neuroscience to examine the effect of pictures on memory performance in AD patients. Two behavioral and two event-related potential (ERP) experiments are proposed to evaluate three specific aims.
Aim 1 will compare discrimination and response bias for pictures versus words in a single experiment systematically varying pictures and words at study and test.
Aim 2 will use standard neuropsychological measures of medial temporal lobe and frontal lobe function to evaluate neuroanatomical regions that may contribute to the effect of pictures on discrimination and response bias in AD. Finally, Aim 3 will use grayscale versus color pictures and a level of processing manipulation to evaluate two hypotheses regarding how pictures might affect memory processes in AD. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AG027632-02
Application #
7242576
Study Section
Special Emphasis Panel (ZRG1-F12A-H (20))
Program Officer
Silverberg, Nina B
Project Start
2006-06-01
Project End
2009-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
2
Fiscal Year
2007
Total Cost
$52,666
Indirect Cost
Name
Boston University
Department
Neurology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Ally, Brandon A; Gold, Carl A; Budson, Andrew E (2009) An evaluation of recollection and familiarity in Alzheimer's disease and mild cognitive impairment using receiver operating characteristics. Brain Cogn 69:504-13
Ally, Brandon A; McKeever, Joshua D; Waring, Jill D et al. (2009) Preserved frontal memorial processing for pictures in patients with mild cognitive impairment. Neuropsychologia 47:2044-55
Ally, Brandon A; Gold, Carl A; Budson, Andrew E (2009) The picture superiority effect in patients with Alzheimer's disease and mild cognitive impairment. Neuropsychologia 47:595-8
Ally, Brandon A; Waring, Jill D; Beth, Ellen H et al. (2008) Aging memory for pictures: using high-density event-related potentials to understand the effect of aging on the picture superiority effect. Neuropsychologia 46:679-89
Simons, Jon S; Peers, Polly V; Hwang, David Y et al. (2008) Is the parietal lobe necessary for recollection in humans? Neuropsychologia 46:1185-91
Ally, Brandon A; Simons, Jon S; McKeever, Joshua D et al. (2008) Parietal contributions to recollection: electrophysiological evidence from aging and patients with parietal lesions. Neuropsychologia 46:1800-12
Ally, Brandon A; Budson, Andrew E (2007) The worth of pictures: using high density event-related potentials to understand the memorial power of pictures and the dynamics of recognition memory. Neuroimage 35:378-95