Public Health Relevance

Human Endogenous Retrovirus K (HERV-K) has been associated with several severe human diseases including, but not limited to, auto-immune diseases, HIV-1 infection, and multiple malignancies. The goal of this project is to better understand the viral lifecycle of the HERV-K family, both in its historical and contemporary context.

Agency
National Institute of Health (NIH)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AI106189-02
Application #
8635207
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Park, Eun-Chung
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Zahn, Joseph; Kaplan, Mark H; Fischer, Sabrina et al. (2015) Expansion of a novel endogenous retrovirus throughout the pericentromeres of modern humans. Genome Biol 16:74
Contreras-Galindo, Rafael; Kaplan, Mark H; Dube, Derek et al. (2015) Human Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K-Related Sequences. J Virol 89:7187-201
Dube, Derek; Contreras-Galindo, Rafael; He, Shirley et al. (2014) Genomic flexibility of human endogenous retrovirus type K. J Virol 88:9673-82