Abstract

Public Health Relevance

Human Endogenous Retrovirus K (HERV-K) has been associated with several severe human diseases including, but not limited to, auto-immune diseases, HIV-1 infection, and multiple malignancies. The goal of this project is to better understand the viral lifecycle of the HERV-K family, both in its historical and contemporary context.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AI106189-02
Application #
8635207
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Park, Eun-Chung
Project Start
2013-06-10
Project End
2015-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Contreras-Galindo, Rafael; Dube, Derek; Fujinaga, Koh et al. (2017) Susceptibility of Human Endogenous Retrovirus Type K to Reverse Transcriptase Inhibitors. J Virol 91:
Contreras-Galindo, Rafael; Kaplan, Mark H; Dube, Derek et al. (2015) Human Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K-Related Sequences. J Virol 89:7187-201
Zahn, Joseph; Kaplan, Mark H; Fischer, Sabrina et al. (2015) Expansion of a novel endogenous retrovirus throughout the pericentromeres of modern humans. Genome Biol 16:74
Dube, Derek; Contreras-Galindo, Rafael; He, Shirley et al. (2014) Genomic flexibility of human endogenous retrovirus type K. J Virol 88:9673-82