Cortical sensory maps are important for perceptual learning. Cortical inhibition has an important role in the formation, maintenance and adaptability of these maps. We hypothesize that long-term potentiation (LTP) of thalamocortical synapses onto inhibitory neurons is important for the refinement of sensory maps.
Specific Aim 1 :
The first aim of this study is to determine if LTP can be elicited at thalamocortical synapses onto inhibitory neurons.
Specific Aim 2 :
The aim of this experiment is to determine if LTP is dependent on NMDA receptors, calcium-permeable AMPA receptors, metabotropic glutamate receptors or L-type voltage dependent calcium channels, using selective receptor antagonists.
Specific Aim 3 :
The aim of this expedment is to determine if LTP of thalamic inputs onto inhibitory neurons is dependent on a critical period. The results of this project will increase our understanding of the mechanisms involve in perceptual learning.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
MARC (NRSA) Faculty Fellowships (F34)
Project #
5F34GM070406-04
Application #
7162508
Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Toliver, Adolphus
Project Start
2003-11-16
Project End
2008-05-15
Budget Start
2006-11-16
Budget End
2007-11-15
Support Year
4
Fiscal Year
2007
Total Cost
$44,110
Indirect Cost
Name
Ponce School of Medicine
Department
Pharmacology
Type
Schools of Medicine
DUNS #
105742043
City
Ponce
State
PR
Country
United States
Zip Code
00732