HIV and Substance of Abuse Laboratory Core The HIV and Substance of Abuse Laboratory Core (H-SALC) will continue providing human and physical resources needed to support studies In the areas of HIV/AIDS and related diseases as well as in substances of abuse. This support is extended to the Retrovirus Research Center, Center for Addiction Study, Comprehensive Center for the Study of HIV Disparities and other centers of the RCMI Program. In addition, it will continue with the existing collaborative activities with at least three communities and government based agencies. Furthermore, it will provide administrative and scientific support to pilot projects with the participation of consultants and mentors. Therefore, the research plan for the Renewal Proposal Is directed toward: 1) Providing a centralized, well-structured laboratory supportive of research activities undertaken by centers and programs, including those handling infectious material and immunodeficiency diseases (HIV/AIDS, HCV, cancer, and vaccine development). 2) Improving and introducing new methodology to test the effect of addiction-related drugs (cocaine, heroin, methamphetamine and, methadone, and buprenorphine) on the immune system, the glial-neuro-network and HIV (i.e., NeuroAIDS), and HCV infectivity. 3) Upgrading and replacing obsolete instrumentation and acquiring new equipment to meet the increasing need of research projects for redirecting their methodology and making it more amenable to the translational research trend, 4) Strengthening existing and new affiliations with community service agencies to facilitate the involvement of specific disease populations in our research and services efforts, 5) Providing scientific and administrative support to pilot projects with the participation of consultants and mentors. To achieve these objectives, a research plan is discussed in the present proposal.
Sustaining RCMI Program funding to H-SALC is crucial to help in establishing mechanisms by which illicit drugs alter human health (i.e., HIV/AIDS and viral hepatitis) and formulate policies conductive at detecting, preventing and treating diseases associated with them.
|Kucheryavykh, Lilia Y; Benedikt, Jan; Cubano, Luis A et al. (2017) Polyamines preserve connexin 43-mediated gap junctional communication during intracellular hypercalcemia and acidosis. Neuroreport 28:208-213|
|Dubrow, Robert; Qin, Li; Lin, Haiqun et al. (2017) Association of CD4+ T-cell Count, HIV-1 RNA Viral Load, and Antiretroviral Therapy With Kaposi Sarcoma Risk Among HIV-infected Persons in the United States and Canada. J Acquir Immune Defic Syndr 75:382-390|
|Suárez-Arroyo, Ivette J; Loperena-Alvarez, Yaliz; Rosario-Acevedo, Raysa et al. (2017) Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer. Medicines (Basel) 4:|
|Rivera, Mariela; Ramos, Yanilda; Rodríguez-Valentín, Madeline et al. (2017) Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells. PLoS One 12:e0179587|
|Drozd, Daniel R; Kitahata, Mari M; Althoff, Keri N et al. (2017) Increased Risk of Myocardial Infarction in HIV-Infected Individuals in North America Compared With the General Population. J Acquir Immune Defic Syndr 75:568-576|
|Jiamsakul, Awachana; Kariminia, Azar; Althoff, Keri N et al. (2017) HIV Viral Load Suppression in Adults and Children Receiving Antiretroviral Therapy-Results From the IeDEA Collaboration. J Acquir Immune Defic Syndr 76:319-329|
|Cruz-Feliciano, Miguel A; Miranda-Díaz, Christine; Fernández-Santos, Diana M et al. (2017) Quality of life improvement in Latinas receiving combined substance use disorders and trauma-specific treatment: a cohort evaluation report. Health Qual Life Outcomes 15:90|
|Inyushin, Mikhail Y; Sanabria, Priscila; Rojas, Legier et al. (2017) A? Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer's Drug Development. Biomed Res Int 2017:3948360|
|Makarov, Vladimir; Zueva, Lidia; Golubeva, Tatiana et al. (2017) Quantum mechanism of light transmission by the intermediate filaments in some specialized optically transparent cells. Neurophotonics 4:011005|
|Shiels, Meredith S; Althoff, Keri N; Pfeiffer, Ruth M et al. (2017) HIV Infection, Immunosuppression, and Age at Diagnosis of Non-AIDS-Defining Cancers. Clin Infect Dis 64:468-475|
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