Abstract

UTSA's proposed RCMI Center for Interdisciplinary Health Research (CIHR) will expand research infrastructure and expertise to establish a program of excellence in basic and translational health research that will advance both the strategic goals of UTSA and RCMI/NCRR. The RCMI CIHR is greatly needed for UTSA to develop present areas of scientific strength into competitive health research programs to advance our strategic mission. The proposed program will foster and guide the development of UTSA faculty whose research has great relevance to human health and will support translational research projects. The Administrative Core will provide leadership and support for activities to advance the center's mission, develop research cores, and provide administrative and academic support for investigators. It will coordinate the IAC/EAC, establish intra- and inter-institutional collaborations, and execute a Faculty Development Plan and Evaluation Program. A Biophotonics Core will acquire cutting-edge imaging technologies to study biological processes at the molecular level in live cells with exceptional detail. A Computational Systems Biology Core will build high-performance computing infrastructure for simulation of biological systems, livecell imaging, and protein biomarker research. A Protein Biomarkers Core will build infrastructure for protein biomarkers discovery for disease diagnosis and targeted therapy, including biomarkers that are specific to minority populations. A Nanotechnology and Human Health Core will build infrastructure to synthesize nanomaterials for diagnostics, drug/gene delivery, tissue engineering, and for use with electron microscopy to produce 3-D structural information at the finest level. Five pilot project PIs will also be developed. Dr Lorenzo Brancaleon: Photo-induced unfolding of cancer-specific membrane receptors;Dr Thomas Forsthuber: Biomarker discovery in glucocorticoid resistance in experimental autoimmune encephalomyelitis;Dr Fidel Santamaria:Structural basis of biochemical information processing in neurons;Dr Tao Wei: Molecular mechanisms of A. baumannii biofilm formation;and Dr Jianqiu Michelle Zhang:Advanced Data Processing for Capillary LC/MS data.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Research Centers in Minority Institutions Award (G12)
Project #
8G12MD007591-13
Application #
8306175
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Sayre, Michael
Project Start
1998-09-30
Project End
2015-06-30
Budget Start
2012-07-03
Budget End
2013-06-30
Support Year
13
Fiscal Year
2012
Total Cost
$2,400,696
Indirect Cost
$739,315

  Institution

Name
University of Texas Health Science Center San Antonio
Department
Type
Other Domestic Higher Education
DUNS #
800189185
City
San Antonio
State
TX
Country
United States
Zip Code
78249

  Publications

Yu, Yang; Sha, Qiang; Cui, Hui et al. (2018) Displacement of Dinitrogen by Oxygen: A Methodology for the Catalytic Conversion of Diazocarbonyl Compounds to Ketocarbonyl Compounds by 2,6-Dichloropyridine-N-oxide. Org Lett 20:776-779
Wang, Yifan; Griffith, Wendell P; Li, Jiasong et al. (2018) Cofactor Biogenesis in Cysteamine Dioxygenase: C-F Bond Cleavage with Genetically Incorporated Unnatural Tyrosine. Angew Chem Int Ed Engl 57:8149-8153
Ortega, Eduardo; Santiago, Ulises; Giuliani, Jason G et al. (2018) In-situ magnetization/heating electron holography to study the magnetic ordering in arrays of nickel metallic nanowires. AIP Adv 8:056813
Das, T; Alabi, I; Colley, M et al. (2018) Major venom proteins of the fire ant Solenopsis invicta: insights into possible pheromone-binding function from mass spectrometric analysis. Insect Mol Biol 27:505-511
Campuzano, Althea; Wormley, Floyd L (2018) Innate Immunity against Cryptococcus, from Recognition to Elimination. J Fungi (Basel) 4:
Hermann, Brian P; Cheng, Keren; Singh, Anukriti et al. (2018) The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids. Cell Rep 25:1650-1667.e8
Wei, Zhen; Panneerdoss, Subbarayalu; Timilsina, Santosh et al. (2018) Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing. Int J Genomics 2018:1351964
Li, Jiasong; Griffith, Wendell P; Davis, Ian et al. (2018) Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase. Nat Chem Biol 14:853-860
Cui, Xiaodong; Zhang, Lin; Meng, Jia et al. (2018) MeTDiff: A Novel Differential RNA Methylation Analysis for MeRIP-Seq Data. IEEE/ACM Trans Comput Biol Bioinform 15:526-534
Beaudoin 3rd, Gerard M J; Gomez, Jorge A; Perkins, Jessica et al. (2018) Cocaine Selectively Reorganizes Excitatory Inputs to Substantia Nigra Pars Compacta Dopamine Neurons. J Neurosci 38:1151-1159

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