Abstract

UTSA's proposed RCMI Center for Interdisciplinary Health Research (CIHR) will expand research infrastructure and expertise to establish a program of excellence in basic and translational health research that will advance both the strategic goals of UTSA and RCMI/NCRR. The RCMI CIHR is greatly needed for UTSA to develop present areas of scientific strength into competitive health research programs to advance our strategic mission. The proposed program will foster and guide the development of UTSA faculty whose research has great relevance to human health and will support translational research projects. The Administrative Core will provide leadership and support for activities to advance the center's mission, develop research cores, and provide administrative and academic support for investigators. It will coordinate the IAC/EAC, establish intra- and inter-institutional collaborations, and execute a Faculty Development Plan and Evaluation Program. A Biophotonics Core will acquire cutting-edge imaging technologies to study biological processes at the molecular level in live cells with exceptional detail. A Computational Systems Biology Core will build high-performance computing infrastructure for simulation of biological systems, livecell imaging, and protein biomarker research. A Protein Biomarkers Core will build infrastructure for protein biomarkers discovery for disease diagnosis and targeted therapy, including biomarkers that are specific to minority populations. A Nanotechnology and Human Health Core will build infrastructure to synthesize nanomaterials for diagnostics, drug/gene delivery, tissue engineering, and for use with electron microscopy to produce 3-D structural information at the finest level. Five pilot project PIs will also be developed. Dr Lorenzo Brancaleon: Photo-induced unfolding of cancer-specific membrane receptors;Dr Thomas Forsthuber: Biomarker discovery in glucocorticoid resistance in experimental autoimmune encephalomyelitis;Dr Fidel Santamaria:Structural basis of biochemical information processing in neurons;Dr Tao Wei: Molecular mechanisms of A. baumannii biofilm formation;and Dr Jianqiu Michelle Zhang:Advanced Data Processing for Capillary LC/MS data.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Research Centers in Minority Institutions Award (G12)
Project #
8G12MD007591-13
Application #
8306175
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Sayre, Michael
Project Start
1998-09-30
Project End
2015-06-30
Budget Start
2012-07-03
Budget End
2013-06-30
Support Year
13
Fiscal Year
2012
Total Cost
$2,400,696
Indirect Cost
$739,315

  Institution

Name
University of Texas Health Science Center San Antonio
Department
Type
Other Domestic Higher Education
DUNS #
800189185
City
San Antonio
State
TX
Country
United States
Zip Code
78249

  Publications

Wei, Zhen; Panneerdoss, Subbarayalu; Timilsina, Santosh et al. (2018) Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing. Int J Genomics 2018:1351964
Li, Jiasong; Griffith, Wendell P; Davis, Ian et al. (2018) Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase. Nat Chem Biol 14:853-860
Cui, Xiaodong; Zhang, Lin; Meng, Jia et al. (2018) MeTDiff: A Novel Differential RNA Methylation Analysis for MeRIP-Seq Data. IEEE/ACM Trans Comput Biol Bioinform 15:526-534
Beaudoin 3rd, Gerard M J; Gomez, Jorge A; Perkins, Jessica et al. (2018) Cocaine Selectively Reorganizes Excitatory Inputs to Substantia Nigra Pars Compacta Dopamine Neurons. J Neurosci 38:1151-1159
Ketter, Patrick M; Yu, Jieh-Juen; Guentzel, M Neal et al. (2018) Acinetobacter baumannii Gastrointestinal Colonization Is Facilitated by Secretory IgA Which Is Reductively Dissociated by Bacterial Thioredoxin A. MBio 9:
Nalawade, Saisha A; Ji, Niannian; Raphael, Itay et al. (2018) Aire is not essential for regulating neuroinflammatory disease in mice transgenic for human autoimmune-diseases associated MHC class II genes HLA-DR2b and HLA-DR4. Cell Immunol 331:38-48
Mace, Brennan; Harrell, Zach; Chen, Chonglin et al. (2018) Role of temperature and oxygen content on structural and electrical properties of LaBaCo2O5+?thin films. Appl Phys Lett 112:073905
Reale, Marcella; D'Angelo, Chiara; Costantini, Erica et al. (2018) Expression Profiling of Cytokine, Cholinergic Markers, and Amyloid-? Deposition in the APPSWE/PS1dE9 Mouse Model of Alzheimer's Disease Pathology. J Alzheimers Dis 62:467-476
Iverson, Grant L; Keene, C Dirk; Perry, George et al. (2018) The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features. J Alzheimers Dis 61:17-28
Ye, Ruquan; Dong, Juncai; Wang, Luqing et al. (2018) Manganese deception on graphene and implications in catalysis. Carbon N Y 132:623-631

Showing the most recent 10 out of 408 publications