This proposal focuses on the continued enhancement and further development of three core research facilities;the expansion of which will ensure Howard University's ability to contribute substantially to studies of diseases that disproportionately affect disadvantaged and minority populations. The three core facilities are the Biomedical Imaging Core Facility, the Proteomics Core Facility, and the Center for Computational Biology &Bioinformatics (CCBB). These core facilities are utilized by a user community of several Investigator-initiated projects. The CCBB will provide a core research facility to support projects in the areas of molecular and quantum mechanical calculations, virtual ligand database screening for drug discovery, statistical genetics and bioinformatics, and computational proteomics. The Biomedical Imaging Core Facility will provide support to projects in the areas of magnetic, molecular, and ultra-structural imaging. The Proteomics Facility will provide support to projects requiring proteomic data analysis or the performance of proteomic procedures. The majority of the projects currently supported by the core facilities are related to the study of cancer or a number of neurological investigations including studies on Alzheimer's disease, synaptic function, schizophrenia, and amygdala functions. AIDS continues to be an important biomedical research Interest of the College of Medicine. A faculty development seminar/workshop series is proposed in order to enhance the productivity and effectiveness of existing and new faculty. This application also proposes to enhance the University's faculty-level work force In the areas of biomedical imaging, computational biology &bioinformatics, and proteomics by providing laboratory start-up support to newly recruited tenure-track faculty. Attainment of these objectives will contribute to Howard University's goals of addressing diseases that disproportionately affect disadvantaged and minority populations.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Research Centers in Minority Institutions Award (G12)
Project #
8G12MD007597-24
Application #
8314116
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Mcclure, Shelia A
Project Start
1997-09-30
Project End
2014-06-30
Budget Start
2012-07-03
Budget End
2013-06-30
Support Year
24
Fiscal Year
2012
Total Cost
$1,888,040
Indirect Cost
$641,664
Name
Howard University
Department
None
Type
Schools of Medicine
DUNS #
056282296
City
Washington
State
DC
Country
United States
Zip Code
20059
Barfield, Whitney L; Uaesoontrachoon, Kitipong; Wu, Chung-Sheih et al. (2014) Eccentric muscle challenge shows osteopontin polymorphism modulation of muscle damage. Hum Mol Genet 23:4043-50
Ilinykh, Philipp A; Tigabu, Bersabeh; Ivanov, Andrey et al. (2014) Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription. J Biol Chem 289:22723-38
Lee, Kwang-Soo; Park, Jong-Lyul; Lee, Kwanbok et al. (2014) nc886, a non-coding RNA of anti-proliferative role, is suppressed by CpG DNA methylation in human gastric cancer. Oncotarget 5:3944-55
Huo, Shuaidong; Jin, Shubin; Ma, Xiaowei et al. (2014) Ultrasmall gold nanoparticles as carriers for nucleus-based gene therapy due to size-dependent nuclear entry. ACS Nano 8:5852-62
Bond Jr, Vernon; Curry, Bryan H; Adams, Richard G et al. (2014) Cardiorespiratory function associated with dietary nitrate supplementation. Appl Physiol Nutr Metab 39:168-72
Ashktorab, Hassan; Paydar, Mansour; Yazdi, Shahla et al. (2014) BMI and the risk of colorectal adenoma in African-Americans. Obesity (Silver Spring) 22:1387-91
Nekhai, Sergei; Hynes, Alla; Ammosova, Tatiana et al. (2014) A128: hierarchical clustering methodology for exploration of proteomic profile in tears: seeking for markers of uveitis associated with juvenile idiopathic arthritis. Arthritis Rheumatol 66 Suppl 11:S168
Ashenafi, Meseret; Ammosova, Tatiana; Nekhai, Sergei et al. (2014) Purification and characterization of aminoglycoside phosphotransferase APH(6)-Id, a streptomycin-inactivating enzyme. Mol Cell Biochem 387:207-16
Shim, Jung Ho; Yoon, Jung Hwan; Choi, Sung Sook et al. (2014) The effect of Helicobacter pylori CagA on the HER-2 copy number and expression in gastric cancer. Gene 546:288-96
Zhang, Xu; Zhang, Wei; Ma, Shwu-Fan et al. (2014) Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing. Blood Cells Mol Dis 52:35-45

Showing the most recent 10 out of 45 publications