The overarching goals of this proposal are twofold: 1) to develop a programmatic line of research aimed at shedding light on the development of alcohol-related problems in adolescence and into adulthood using an intermediate phenotype maximum 24-hr alcohol consumption that has shown considerable promise as an indicator of risk in preliminary studies; and 2) to augment the applicant's training in developmental psychology with additional training in psychopathology, statistical methods for longitudinal data analysis, neuroscience, genetics (behavioral genetics, genetic epidemiology, and other quantitative methods), and advanced methods of event-related potential and magnetic resonance imaging analysis of brain structure and dynamics. The proposed research plan will build on findings that maximum consumption appears to relate more directly to the mechanisms conferring risk for SUDs than a psychiatric diagnosis of alcohol dependence and will use a developmentally and genetically-informed, multimethod approach to 1) evaluate the construct validity of the maximum consumption phenotype, 2) describe developmental trajectories among adolescent youth in relation to substance abuse risk and 3) to characterize neural dynamics among high-risk adolescents. The training activities will better prepare the applicant to conduct the proposed research, and the award would provide the freedom to pursue systematic research on this important phenotype. Together these will allow the applicant to pursue his ultimate goal as an independent researcher investigating neural processes associated with externalizing disorders and substance abuse. In addition, this research is likely to yield theoretically and clinically useful findings. It will extend previous research on electrophysiological correlates of substance abuse risk and ultimately holds significant promise for intervention efforts with high-risk individuals. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
1K01AA015621-01A1
Application #
7039343
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Arroyo, Judith A
Project Start
2006-09-01
Project End
2011-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
1
Fiscal Year
2006
Total Cost
$68,716
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Bornovalova, Marina A; Verhulst, Brad; Webber, Troy et al. (2018) Genetic and environmental influences on the codevelopment among borderline personality disorder traits, major depression symptoms, and substance use disorder symptoms from adolescence to young adulthood. Dev Psychopathol 30:49-65
Yoon, Henry H; Malone, Stephen M; Iacono, William G (2015) Longitudinal stability and predictive utility of the visual P3 response in adults with externalizing psychopathology. Psychophysiology 52:1632-45
Malone, Stephen M; Vaidyanathan, Uma; Basu, Saonli et al. (2014) Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. Psychophysiology 51:1246-58
Bornovalova, M A; Cummings, J R; Hunt, E et al. (2014) Understanding the relative contributions of direct environmental effects and passive genotype-environment correlations in the association between familial risk factors and child disruptive behavior disorders. Psychol Med 44:831-44
Bornovalova, Marina A; Huibregtse, Brooke M; Hicks, Brian M et al. (2013) Tests of a direct effect of childhood abuse on adult borderline personality disorder traits: a longitudinal discordant twin design. J Abnorm Psychol 122:180-94
Yoon, Henry H; Malone, Stephen M; Burwell, Scott J et al. (2013) Association between P3 event-related potential amplitude and externalizing disorders: a time-domain and time-frequency investigation of 29-year-old adults. Psychophysiology 50:595-609
Ethridge, Lauren E; Malone, Stephen M; Iacono, William G et al. (2013) Genetic influences on composite neural activations supporting visual target identification. Biol Psychol 92:329-41
Bornovalova, Marina A; Blazei, Ryan; Malone, Stephen H et al. (2013) Disentangling the relative contribution of parental antisociality and family discord to child disruptive disorders. Personal Disord 4:239-46
Bornovalova, Marina A; Hicks, Brian M; Iacono, William G et al. (2013) Longitudinal twin study of borderline personality disorder traits and substance use in adolescence: developmental change, reciprocal effects, and genetic and environmental influences. Personal Disord 4:23-32
Gilmore, Casey S; Malone, Stephen M; Iacono, William G (2012) Is the P3 amplitude reduction seen in externalizing psychopathology attributable to stimulus sequence effects? Psychophysiology 49:248-51

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