Despite a greater accumulation of risk factors for at-risk drinking and alcohol use disorders, national epidemiological surveys consistently report that Blacks and Hispanics in the United States (US) have an comparable or lower prevalence of binge drinking and alcohol disorders compared to non-Hispanic Whites. However, mortality data indicate that they have higher rates of alcohol-attributable motor vehicle crash fatality (MVCF). These seemingly divergent patterns indicate an epidemiologic paradox, the consequences of which are important for public health: MVCF is a leading cause of death among young adults, Blacks and Hispanics experience substantial inequities in MVCF compared to non-Hispanic Whites, and approximately 30% of all MVCFs are alcohol-related. In the present application for a Mentored Research Scientist Development Award (K01), I propose to develop expertise in four areas that will allow me to develop a line of research into the racial/ethnic paradox in alcohol-related health: 1) Built environment effects on alcohol-related health;2) Conceptualization and measurement of cultural and social norms regarding alcohol use;3) Analysis of repeated measures data;and 4) Field methods in epidemiologic data collection. I will use the skills obtained in these training areas to begin to fill outstanding gaps in our understanding of racial/ethnic differences in alcohol- related health with three research projects, for which the K01 will allow me protected research time that would otherwise not be possible as a new assistant professor. First, I will probe the validity of the racial/ethnic paradox itself. I ill explore whether lower rates of problem drinking among racial/ethnic minorities are limited to adolescents and young adults, and whether rates of problem drinking among older adults are higher among Blacks and Hispanics compared to non-Hispanic Whites. This work will utilize a national longitudinal dataset and incorporate information on trajectories within Blacks and Latino subgroups, which have never been characterized. Second, I will determine if alcohol-related social norms mediate overall differences in alcohol use and MVC risk, adding to our knowledge of how the paradox arises. I will use data from the New York Social Environment Survey, an epidemiologic study in New York City with rich racial and ethnic diversity and one of the only community-based samples to measure alcohol norms. Third, I will test a potential mechanism to explain the racial/ethnic paradox: that Black and Hispanic individuals experience more alcohol-attributable MVCF because the built environment in which they consume alcohol is more dangerous (e.g., worse road conditions). To test this hypothesis I propose a novel study linking records from the Fatality Analysis Reporting System on a national level with census and land usage information. In addition to these research aims, my K01 award period will focus on preparation of an R01 grant proposal to collect original data on racial/ethnic differences in alcohol-related health that builds on and extends the research proposed here. These projects are feasible only if I have protected time for new training and research, which K01 funding will provide.

Public Health Relevance

The present proposal examines a long-standing but little investigated 'paradox'in alcohol epidemiology: epidemiological surveys consistently report that Black and Latino populations have comparable or lower prevalence of alcohol disorders compared to non-Hispanic Whites, but bear a disproportionate amount of harm from alcohol in the form of injury and illness. The training and research proposed here will form the background of a new line of inquiry to examine how racial/ethnic differences are shaped over the life course, and how the built environment as well as cultural/social norms shape alcohol-related risk. These inquires have substantial promise for public health;accurate empirical data regarding the emergence of racial/ethnic differences across the life course and explanations for the epidemiologic 'paradox'in alcohol-related health are crucial to better understanding the role of minority status in the development and persistence of alcohol disorders as well as alcohol-related motor-vehicle crash risk.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Scientist Development Award - Research & Training (K01)
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Biomedical Research Review Subcommittee (AA)
Program Officer
Godette, Dionne
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Columbia University (N.Y.)
Public Health & Prev Medicine
Schools of Public Health
New York
United States
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Keyes, Katherine M; Hamilton, Ava; Kandel, Denise B (2016) Birth Cohorts Analysis of Adolescent Cigarette Smoking and Subsequent Marijuana and Cocaine Use. Am J Public Health 106:1143-9
Kalesan, Bindu; Villarreal, Marcos D; Keyes, Katherine M et al. (2016) Gun ownership and social gun culture. Inj Prev 22:216-20
Reininghaus, Ulrich; Keyes, Katherine M; Morgan, Craig (2016) Novel methods in psychiatric epidemiology. Soc Psychiatry Psychiatr Epidemiol 51:917-9
Walsh, Kate; Hasin, Deborah; Keyes, Katherine M et al. (2016) Associations between gender-based violence and personality disorders in U.S. women. Personal Disord 7:205-10
McLaughlin, Katie A; Basu, Archana; Walsh, Kate et al. (2016) Childhood Exposure to Violence and Chronic Physical Conditions in a National Sample of US Adolescents. Psychosom Med 78:1072-1083
Kuijpers, Rowella C W M; Otten, Roy; Vermulst, Ad A et al. (2016) Reliability, factor structure, and measurement invariance of the Dominic Interactive across European countries: Cross-country utility of a child mental health self-report. Psychol Assess 28:539-48
Lee, Yvonne C; Agnew-Blais, Jessica; Malspeis, Susan et al. (2016) Post-Traumatic Stress Disorder and Risk for Incident Rheumatoid Arthritis. Arthritis Care Res (Hoboken) 68:292-8
Kovess-Masfety, Viviane; Keyes, Katherine; Hamilton, Ava et al. (2016) Is time spent playing video games associated with mental health, cognitive and social skills in young children? Soc Psychiatry Psychiatr Epidemiol 51:349-57
Talati, A; Keyes, K M; Hasin, D S (2016) Changing relationships between smoking and psychiatric disorders across twentieth century birth cohorts: clinical and research implications. Mol Psychiatry 21:464-71
Palamar, Joseph J; Keyes, Katherine; Cleland, Charles M (2016) Underreporting of ecstasy use among high school seniors in the US. Drug Alcohol Depend 165:279-82

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