The applicant, Dr. Samir S. Shah, is requesting five years of funding through the Mentored Research Scientist Development Award to enhance methodological skills required to conduct observational and interventional research on community-acquired pneumonia (CAP), a common and serious infection in children. The proposed training goals, including skills in advanced epidemiology and biostatistical methods, will allow the applicant to pursue methodologically sound, technically feasible, and innovative research approaches. The applicant's strong background of research and clinical training in pediatrics, infectious diseases, and epidemiology provides an excellent foundation for this work. The award will promote the development of Dr. Shah as an independent clinical investigator. The proposal will use an existing practice-based research network to conduct population-based cohort studies with the following specific aims: First, he will determine the incidence of and identify risk factors for adverse outcomes among children with CAP. Second, he will develop a simple and practical clinical prediction rule that would accurately predict the risk of a child with CAP developing an adverse clinical outcome. Third, the clinical prediction rule will be validated in an independent sample of ethnically and geographically diverse children, thus demonstrating its generalizability. Addressing the above specific aims will allow the identification of a high-risk population of children with CAP who may be suitable candidates for subsequent studies of therapeutic interventions (e.g., new antibiotics, immunomodulators) to improve clinical outcomes. The methods for case finding, study recruitment, data abstraction, clinical outcome validation, and patient follow-up established during this study will facilitate the conduct of future observational and interventional studies of children with CAP within this practice-based research network. The mentoring relationships, advanced formal training and education, and protected time afforded by the award will raise the sophistication, rigor, and quality of Dr. Shah's work and significantly facilitate his transition to a highly successful, independent, clinical investigator. Dr. Shah's research will improve our understanding of CAP and, from a public health perspective, will provide methods to risk stratify children with CAP and will establish a rational basis to target prevention efforts at those children at highest risk for developing CAP-related adverse clinical outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AI073729-06
Application #
8213383
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Taylor, Christopher E,
Project Start
2008-02-01
Project End
2013-01-31
Budget Start
2012-02-01
Budget End
2013-01-31
Support Year
6
Fiscal Year
2012
Total Cost
$151,711
Indirect Cost
$9,392
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Thomson, Joanna; Ambroggio, Lilliam; Murtagh Kurowski, Eileen et al. (2015) Hospital outcomes associated with guideline-recommended antibiotic therapy for pediatric pneumonia. J Hosp Med 10:13-8
Pasquali, Sara K; Peterson, Eric D; Jacobs, Jeffrey P et al. (2013) Differential case ascertainment in clinical registry versus administrative data and impact on outcomes assessment for pediatric cardiac operations. Ann Thorac Surg 95:197-203
Pasquali, Sara K; He, Xia; Jacobs, Marshall L et al. (2013) Hospital variation in postoperative infection and outcome after congenital heart surgery. Ann Thorac Surg 96:657-63
Blaschke, Anne J; Byington, Carrie L; Ampofo, Krow et al. (2013) Species-specific PCR improves detection of bacterial pathogens in parapneumonic empyema compared with 16S PCR and culture. Pediatr Infect Dis J 32:302-3
Shah, Samir S; Test, Matthew; Sheffler-Collins, Seth et al. (2012) Macrolide therapy and outcomes in a multicenter cohort of children hospitalized with Mycoplasma pneumoniae pneumonia. J Hosp Med 7:311-7
Neuman, Mark I; Lee, Edward Y; Bixby, Sarah et al. (2012) Variability in the interpretation of chest radiographs for the diagnosis of pneumonia in children. J Hosp Med 7:294-8
Pasquali, Sara K; Li, Jennifer S; He, Xia et al. (2012) Comparative analysis of antifibrinolytic medications in pediatric heart surgery. J Thorac Cardiovasc Surg 143:550-7
Pasquali, Sara K; Li, Jennifer S; He, Xia et al. (2012) Perioperative methylprednisolone and outcome in neonates undergoing heart surgery. Pediatrics 129:e385-91
Pati, Susmita; Lorch, Scott A; Lee, Grace E et al. (2012) Health insurance and length of stay for children hospitalized with community-acquired pneumonia. J Hosp Med 7:304-10
Macy, Michelle L; Hall, Matthew; Shah, Samir S et al. (2012) Differences in designations of observation care in US freestanding children's hospitals: are they virtual or real? J Hosp Med 7:287-93

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