In the previous cycle of this award, the candidate designed and implemented studies that combined Positron Emission Tomography (PET) receptor imaging with clinical outcome measures in addiction. These studies were designed to image changes in neurobiology that occur in the setting of addiction and to develop biomarkers of clinical response, such as drug seeking behavior or treatment response. In addition, the candidate engaged in a number of successful collaborations that have enabled her to implement other imaging modalities, such as functional magnetic resonance imaging and magnetic resonance spectroscopy, with PET neuroreceptor imaging. In the next cycle of this award, the aims of the candidate are to use PET in combination with clinical trials and to implement PET studies in preclinical animal models of addiction. These studies are designed to examine the neurobiology of addiction, and to investigate the efficacy of medications or interventions that might reverse these changes. These studies involve the establishment of new collaborations and the implementation of novel methods.
Previous work performed by the applicant for this award have shown that PET imaging can be used to develop biomarkers of drug seeking behavior and treatment response in addiction. The next set of studies will allow the candidate to implement PET studies that complement clinical trials in substance use disorders and to explore the mechanism using animal models of addiction.
|Salling, Michael C; Martinez, Diana (2016) Brain Stimulation in Addiction. Neuropsychopharmacology 41:2798-2809|
|Luo, Sean X; Martinez, Diana; Carpenter, Kenneth M et al. (2014) Multimodal predictive modeling of individual treatment outcome in cocaine dependence with combined neuroimaging and behavioral predictors. Drug Alcohol Depend 143:29-35|
|Trifilieff, Pierre; Martinez, Diana (2014) Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity. Neuropharmacology 76 Pt B:498-509|
|Tau, Gregory Z; Marsh, Rachel; Wang, Zhishun et al. (2014) Neural correlates of reward-based spatial learning in persons with cocaine dependence. Neuropsychopharmacology 39:545-55|
|Martinez, Diana; Slifstein, Mark; Nabulsi, Nabeel et al. (2014) Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy. Biol Psychiatry 75:165-71|
|Martinez, Diana; Saccone, Phillip A; Liu, Fei et al. (2012) Deficits in dopamine D(2) receptors and presynaptic dopamine in heroin dependence: commonalities and differences with other types of addiction. Biol Psychiatry 71:192-8|
|Martinez, Diana; Carpenter, Kenneth M; Liu, Fei et al. (2011) Imaging dopamine transmission in cocaine dependence: link between neurochemistry and response to treatment. Am J Psychiatry 168:634-41|
|Martinez, Diana; Orlowska, Daria; Narendran, Rajesh et al. (2010) Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers. Biol Psychiatry 67:275-8|