In the previous cycle of this award, the candidate designed and implemented studies that combined Positron Emission Tomography (PET) receptor imaging with clinical outcome measures in addiction. These studies were designed to image changes in neurobiology that occur in the setting of addiction and to develop biomarkers of clinical response, such as drug seeking behavior or treatment response. In addition, the candidate engaged in a number of successful collaborations that have enabled her to implement other imaging modalities, such as functional magnetic resonance imaging and magnetic resonance spectroscopy, with PET neuroreceptor imaging. In the next cycle of this award, the aims of the candidate are to use PET in combination with clinical trials and to implement PET studies in preclinical animal models of addiction. These studies are designed to examine the neurobiology of addiction, and to investigate the efficacy of medications or interventions that might reverse these changes. These studies involve the establishment of new collaborations and the implementation of novel methods.

Public Health Relevance

Previous work performed by the applicant for this award have shown that PET imaging can be used to develop biomarkers of drug seeking behavior and treatment response in addiction. The next set of studies will allow the candidate to implement PET studies that complement clinical trials in substance use disorders and to explore the mechanism using animal models of addiction.

Agency
National Institute of Health (NIH)
Type
Research Scientist Development Award - Research (K02)
Project #
2K02DA026525-06
Application #
8767764
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Grant, Steven J
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10032