In the previous cycle of this award, the candidate designed and implemented studies that combined Positron Emission Tomography (PET) receptor imaging with clinical outcome measures in addiction. These studies were designed to image changes in neurobiology that occur in the setting of addiction and to develop biomarkers of clinical response, such as drug seeking behavior or treatment response. In addition, the candidate engaged in a number of successful collaborations that have enabled her to implement other imaging modalities, such as functional magnetic resonance imaging and magnetic resonance spectroscopy, with PET neuroreceptor imaging. In the next cycle of this award, the aims of the candidate are to use PET in combination with clinical trials and to implement PET studies in preclinical animal models of addiction. These studies are designed to examine the neurobiology of addiction, and to investigate the efficacy of medications or interventions that might reverse these changes. These studies involve the establishment of new collaborations and the implementation of novel methods.

Public Health Relevance

Previous work performed by the applicant for this award have shown that PET imaging can be used to develop biomarkers of drug seeking behavior and treatment response in addiction. The next set of studies will allow the candidate to implement PET studies that complement clinical trials in substance use disorders and to explore the mechanism using animal models of addiction.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Scientist Development Award - Research (K02)
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Application #
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Grant, Steven J
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Columbia University (N.Y.)
Schools of Medicine
New York
United States
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Martinez, Diana; Urban, Nina; Grassetti, Alex et al. (2018) Transcranial Magnetic Stimulation of Medial Prefrontal and Cingulate Cortices Reduces Cocaine Self-Administration: A Pilot Study. Front Psychiatry 9:80
Salling, Michael C; Martinez, Diana (2016) Brain Stimulation in Addiction. Neuropsychopharmacology 41:2798-2809
Cooper, Ziva D; Johnson, Kirk W; Pavlicova, Martina et al. (2016) The effects of ibudilast, a glial activation inhibitor, on opioid withdrawal symptoms in opioid-dependent volunteers. Addict Biol 21:895-903
Chavkin, Charles; Martinez, Diana (2015) Kappa Antagonist JDTic in Phase 1 Clinical Trial. Neuropsychopharmacology 40:2057-8
Broft, Allegra; Slifstein, Mark; Osborne, Joseph et al. (2015) Striatal dopamine type 2 receptor availability in anorexia nervosa. Psychiatry Res 233:380-7
Horga, Guillermo; Maia, Tiago V; Marsh, Rachel et al. (2015) Changes in corticostriatal connectivity during reinforcement learning in humans. Hum Brain Mapp 36:793-803
Trifilieff, Pierre; Martinez, Diana (2014) Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity. Neuropharmacology 76 Pt B:498-509
Luo, Sean X; Martinez, Diana; Carpenter, Kenneth M et al. (2014) Multimodal predictive modeling of individual treatment outcome in cocaine dependence with combined neuroimaging and behavioral predictors. Drug Alcohol Depend 143:29-35
Martinez, Diana; Slifstein, Mark; Nabulsi, Nabeel et al. (2014) Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy. Biol Psychiatry 75:165-71
Trifilieff, Pierre; Martinez, Diana (2014) Blunted dopamine release as a biomarker for vulnerability for substance use disorders. Biol Psychiatry 76:4-5

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