The immune system prevents reactivity against oneself;when this fails, autoimmune disease results. In pregnancy, the immune system also protects the fetus from the mother's immune system. When a mother develops preeclampsia, her immune system is overly active. Studies have shown that her cells react to her fetus's cells more than in normal pregnancies. This may represent "rejection" of the fetus. Two types of immune cells are especially important in preventing reactions against oneself and the fetus. We propose to evaluate these cells;both number and function, in preeclampsia. If confirmed, problems with these cells may be targets for treatment. In addition, cells exchanged between a woman and her fetus, which is a normal part of pregnancy, contribute to the ability of the immune system to maintain tolerance during pregnancy and later in life. Additional studies aim to understand how this exchange of cells influences pregnancy outcomes.

Public Health Relevance

The proposed studies seek to understand why preeclampsia, a disease unique to pregnancy, develops. Preeclampsia is one of the leading causes of death and disease for women and their children globally. Understanding factors that lead to preeclampsia may lead to new strategies to treat or prevent its occurrence.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HD067221-03
Application #
8677613
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Ilekis, John V
Project Start
2012-06-01
Project End
2017-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
3
Fiscal Year
2014
Total Cost
$128,898
Indirect Cost
$9,548
Name
University of Washington
Department
None
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Vanderhoeven, J P; Peterson, S E; Gannon, E E et al. (2014) Neonatal morbidity occurs despite pulmonary maturity prior to 39 weeks gestation. J Perinatol 34:322-5
Gammill, Hilary S; Stephenson, Mary D; Aydelotte, Tessa M et al. (2014) Microchimerism in recurrent miscarriage. Cell Mol Immunol 11:589-94
Gammill, Hilary S; Aydelotte, Tessa M; Guthrie, Katherine A et al. (2013) Cellular fetal microchimerism in preeclampsia. Hypertension 62:1062-7
Snyder, Matthew W; Simmons, LaVone E; Kitzman, Jacob O et al. (2013) Noninvasive fetal genome sequencing: a primer. Prenat Diagn 33:547-54