I am obstetrician/gynecologist who recently completed a Schizophrenia Research Fellowship and an MPH in Epidemiology at the NewYork State Psychiatric Institute and Columbia University. I have now been recruited as a Research Assistant Professor to New York University's School of Medicine in the Department Psychiatry to contribute to the nucleus of the new Division of Molecular and Translational Medicine in Psychiatry. A major focus of this new Division will be to study the role of aberrant fetal neurodevelopment and adult neuropsychiatric outcomes. After discussion with my mentors, I have designed a rigorous training program consisting of formal coursework in epidemiology and statistics and the neurobiology of psychiatric disorders, laboratory training using animal models, management of large databases and training in ethical research. As a schizophrenia research fellow, I became increasingly interested in the effects of stress during pregnancy and neuropsychiatric outcomes in the offspring through my work with Dr. Dolores Malaspina, my primary mentor on this training grant. As an outgrowth of my work with Dr. Malaspina, I performed a study using animal models investigating stress during pregnancy and the behavioral outcomes of offspring in Dr. Michael Myers's (a mentor on this grant) laboratory at Columbia University. Through this work I became intensely interested in this area of study. As part of the research component of this grant, I will perform three epidemiologic studies. using existing databases, investigating the effects of acute stress in the population on women during pregnancy and the neuropsychiatric and neurocognitive outcomes of their offspring. In addition I will perform a series of experiments to examine neurobehavioral outcomes in offspring of pregnant rats administered glucocortoids during specific times of gestation. These complementary epidemiologic and animal model studies, along with the mentoring and training I will receive, will ensure that at the completion of this award I will be a successful independent scientist.
There have been many natural and manmade disasters in 2008. It is important to model the risk for psychopathology that is related to intrauterine exposure to violence and trauma. The work proposed here can help identify risk factors for psychiatric illnesses and can lay the foundation for the development of targeted interventions to reduce the risk of psychiatric disease.
|Kleinhaus, Karine; Harlap, Susan; Perrin, Mary et al. (2013) Prenatal stress and affective disorders in a population birth cohort. Bipolar Disord 15:92-9|
|Kleinhaus, Karine; Harlap, Susan; Perrin, Mary C et al. (2012) Catatonic schizophrenia: a cohort prospective study. Schizophr Bull 38:331-7|
|Torche, Florencia; Kleinhaus, Karine (2012) Prenatal stress, gestational age and secondary sex ratio: the sex-specific effects of exposure to a natural disaster in early pregnancy. Hum Reprod 27:558-67|
|Lee, Hyejoo; Malaspina, Dolores; Ahn, Hongshik et al. (2011) Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means clustering analysis. Schizophr Res 128:143-9|
|Kleinhaus, K; Harlap, S; Perrin, M et al. (2011) Age, sex and first treatment of schizophrenia in a population cohort. J Psychiatr Res 45:136-41|
|Sullivan, Regina; Perry, Rosemarie; Sloan, Aliza et al. (2011) Infant bonding and attachment to the caregiver: insights from basic and clinical science. Clin Perinatol 38:643-55|
|Perrin, Mary; Harlap, Susan; Kleinhaus, Karine et al. (2010) Older paternal age strongly increases the morbidity for schizophrenia in sisters of affected females. Am J Med Genet B Neuropsychiatr Genet 153B:1329-35|
|Perrin, Mary; Kleinhaus, Karine; Messinger, Julie et al. (2010) Critical periods and the developmental origins of disease: an epigenetic perspective of schizophrenia. Ann N Y Acad Sci 1204 Suppl:E8-13|
|Opler, Mark G A; Harlap, Susan; Ornstein, Katherine et al. (2010) Time-to-pregnancy and risk of schizophrenia. Schizophr Res 118:76-80|