This revised application from the Medical University of South Carolina (MUSC) requests support to establish a Mentored Clinical Scientists Development Program in Drug Abuse and Addiction (K12) at MUSC. The overall objective of the proposed program is to establish an intensive program of mentored clinical research training and career development activities that will promote Scholars'research independence in the area of drug abuse and addiction. In keeping with the mission of NIDA, a major aim of the proposed program is to attract and train clinical researchers to ensure that a diverse pool of highly trained scientists will be available to address the Nation's critical health care needs in te area of addictions. The proposed program, described in detail in the Program Plan section, consists of a unified core curriculum designed to address the following six objectives: (1) Increase addiction knowledge base;(2) Provide fundamental clinical research skills;(3) Enhance statistical skills;(4) Enhance research presentation skills;(5) Improve scientific writin skills;and (6) Provide professional development opportunities. A comprehensive evaluation utilizing formative and summative techniques, as well as recurrent formal and informal approaches for reviewing and evaluating both Scholar progress and program effectiveness will be conducted. Research training and career development opportunities in drug abuse and addictions are exceptionally strong at MUSC, as evidenced by ongoing, NIH-sponsored investigations targeting cocaine, prescription opioids, cannabis, methamphetamine, nicotine, and alcohol addiction. Investigations include studies of the biological mechanisms of addiction, behavioral laboratory studies, psychotherapeutic interventions, pharmacologic clinical trials, and neuroimaging studies. The substantial expertise in the area of clinical drug abuse and addiction research assures our ability to attract, train and prepare Scholars for independent research. The establishment of the NIDA K12 program at MUSC would meet an urgent need to extend the addictions research training potential to faculty-level trainees and allow us to work synergistically with existing pre-doctoral and post-doctoral training programs on campus to attract and promote career development in clinical research focused on addictions throughout the educational continuum.

Public Health Relevance

The participation of clinician-scientists in the biomedical research enterprise helps bridge the gap between basic science and clinical practice. Intensive, mentored clinical training focused on drug abuse and addiction will help ensure that there is a diverse pool of highly trained clinician-scientists available to address the Nation's critical healh care needs.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Physician Scientist Award (Program) (PSA) (K12)
Project #
Application #
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Aklin, Will
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
Schools of Medicine
United States
Zip Code
Hanson, Rochelle F; Schoenwald, Sonja; Saunders, Benjamin E et al. (2016) Testing the Community-Based Learning Collaborative (CBLC) implementation model: a study protocol. Int J Ment Health Syst 10:52
McCauley, Jenna L; Leite, Renata S; Melvin, Cathy L et al. (2016) Dental opioid prescribing practices and risk mitigation strategy implementation: Identification of potential targets for provider-level intervention. Subst Abus 37:9-14
Squeglia, Lindsay M; Ball, Tali M; Jacobus, Joanna et al. (2016) Neural Predictors of Initiating Alcohol Use During Adolescence. Am J Psychiatry :appiajp201615121587
Brady, Kathleen T; McCauley, Jenna L; Back, Sudie E (2016) Prescription Opioid Misuse, Abuse, and Treatment in the United States: An Update. Am J Psychiatry 173:18-26
Cohen, Joseph R; Adams, Zachary W; Menon, Suvarna V et al. (2016) How should we screen for depression following a natural disaster? An ROC approach to post-disaster screening in adolescents and adults. J Affect Disord 202:102-9
Adams, Zachary W; McCauley, Jenna L; Back, Sudie E et al. (2016) Clinician Perspectives on Treating Adolescents with Co-occurring Post-Traumatic Stress Disorder, Substance Use, and Other Problems. J Child Adolesc Subst Abuse 25:575-583
Squeglia, Lindsay M; Baker, Nathaniel L; McClure, Erin A et al. (2016) Alcohol use during a trial of N-acetylcysteine for adolescent marijuana cessation. Addict Behav 63:172-7
Squeglia, Lindsay M; Brammer, Whitney A; Ray, Lara A et al. (2016) Attention Deficit/Hyperactivity Disorder (ADHD) Symptoms Predict Alcohol Expectancy Development. J Child Adolesc Subst Abuse 25:159-179
Tomko, Rachel L; Saladin, Michael E; McClure, Erin A et al. (2016) Alcohol consumption as a predictor of reactivity to smoking and stress cues presented in the natural environment of smokers. Psychopharmacology (Berl) :
Adams, Zachary W; Moreland, Angela; Cohen, Joseph R et al. (2016) Polyvictimization: Latent profiles and mental health outcomes in a clinical sample of adolescents. Psychol Violence 6:145-155

Showing the most recent 10 out of 54 publications