This is an institutional training grant proposal to educate the next generation of clinician-scientists for academic positions in Ophthalmology. For over 38 years, the Duke University Eye Center (DUEC) has been a national leader in training academic Ophthalmologists. The earliest generations of these trainees now serve in numerous leadership positions in academic medical centers across the country and abroad. They have roles as Deans, Department Chairs, and faculty members and serve as mentors for academicians. We propose to continue this tradition through an intensive program designed to provide the guidance, resources, and didactic teaching necessary to produce clinician-scientists for academic positions in Ophthalmology. We plan to select two trainees each year after their completion of a residency in Ophthalmology or Pathology for an intense 3 year educational program that will lead to independent peer-reviewed grant funding and a faculty position in an academic institution. The trainees will undergo an intensive didactic curriculum combined with a close mentorship by senior faculty at Duke University. Each trainee will receive mandatory training in areas of clinical research, genetics, statistics, scientific writing, grant preparation, ethics, and the responsible conduct of research. Each trainee will participate in significant original research and learn the essential skills to develop a successful and independent academic career. Additional aspects of the curriculum of each trainee will be tailored by the program director and lead mentor based upon the selected primary research track and his/her skills, background and career goals. We propose five primary research tracks: (1) translational medicine and clinical trials, (2) clinics and bedside to the bench, (3) Ophthalmic genomics and proteomics, (4) ophthalmic pathology, (5) outcomes and health policy. Because of an international shortage of Ophthalmic Pathologists we will attempt to recruit and appropriate individuals for a research career involving the use of ocular tissues derived from patients and experimental models.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12EY016333-09
Application #
8513331
Study Section
Special Emphasis Panel (ZEY1-VSN (10))
Program Officer
Agarwal, Neeraj
Project Start
2004-09-30
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
9
Fiscal Year
2013
Total Cost
$682,568
Indirect Cost
$48,709
Name
Duke University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Allingham, Michael J; Nie, Qing; Lad, Eleonora M et al. (2016) Semiautomatic Segmentation of Rim Area Focal Hyperautofluorescence Predicts Progression of Geographic Atrophy Due to Dry Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci 57:2283-9
Lad, Eleonora M; Cousins, Scott W; Proia, Alan D (2016) Identity of pigmented subretinal cells in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 254:1239-41
Chandramohan, Arthika; Stinnett, Sandra S; Petrowski, John T et al. (2016) VISUAL FUNCTION MEASURES IN EARLY AND INTERMEDIATE AGE-RELATED MACULAR DEGENERATION. Retina 36:1021-31
Allingham, Michael J (2016) Bilateral Proliferative Retinopathy Associated With Hoyeraal-Hreidarsson Syndrome, a Severe Form of Dyskeratosis Congenita. Ophthalmic Surg Lasers Imaging Retina 47:366-8
Stone, Jordan S; Muir, Kelly W; Stinnett, Sandra S et al. (2015) Glaucoma Blindness at a Tertiary Eye Care Center. N C Med J 76:211-8
Lad, Eleonora M; Cousins, Scott W; Van Arnam, John S et al. (2015) Abundance of infiltrating CD163+ cells in the retina of postmortem eyes with dry and neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 253:1941-5
Estrada, Rolando; Allingham, Michael J; Mettu, Priyatham S et al. (2015) Retinal Artery-Vein Classification via Topology Estimation. IEEE Trans Med Imaging 34:2518-34
Rabbani, Hossein; Allingham, Michael J; Mettu, Priyatham S et al. (2015) Fully automatic segmentation of fluorescein leakage in subjects with diabetic macular edema. Invest Ophthalmol Vis Sci 56:1482-92
Tseng, Henry C; Riday, Thorfinn T; McKee, Celia et al. (2015) Visual impairment in an optineurin mouse model of primary open-angle glaucoma. Neurobiol Aging 36:2201-12
Moore, Daniel B; Neustein, Rebecca F; Jones, Sarah K et al. (2015) Pediatric glaucoma medical therapy: who more accurately reports medication adherence, the caregiver or the child? Clin Ophthalmol 9:2209-12

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