The primary aim of this proposal is to develop and train five vascular medicine specialists who will be prepared to become leaders in the clinical care and clinical investigation of vascular medicine. Northwestern University's Feinberg School of Medicine (NUFSM) has a strong history of national leadership within vascular medicine and is ideally positioned to respond to the need for training superior clinician investigators in vascular medicine. We have capitalized on existing resources available at Northwestern University to organize a well-integrated, highly multi-disciplinary training program in vascular medicine. The Executive Committee leading this proposed program consists of nationally renowned leaders in vascular medicine, vascular surgery, and cardiovascular epidemiology and prevention. We have assembled 10 superior primary mentors from 6 departments who have vibrant, well-funded research programs in vascular medicine and substantial mentoring experience. A highly interactive, well integrated Multidisciplinary Advisory Committee (MAC) will provide oversight and evaluation and has already met to assist in the development of this program. Members of our MAC are key leaders within NUFSM who are well positioned to ensure the success of our program. NUFSM has many programs and resources currently in place that will facilitate the training of outstanding clinician investigators in vascular medicine. These include our NIH-funded GCRC, the Master of Science in Clinical Investigation program with the associated K30 Clinical Research Curriculum Program, a well funded biostatistical support service dedicated to cardiovascular epidemiology investigation, and the newly formed Bluhm Cardiovascular Institute that provides coordinated care of patients with vascular diseases. Finally, capitalizing on Northwestern's nationally acclaimed Kellogg School of Management, our vascular medicine program will include formal training in leadership skills, team building, and other proficiencies important for the development of future leaders in the field of vascular medicine. By training superior clinical investigators, mentors, and leaders in vascular medicine, our training program is expected to improve care and prevent morbidity, mortality, and disability in the growing number of patients with non-coronary vascular disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Physician Scientist Award (Program) (PSA) (K12)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-A (F1))
Program Officer
Scott, Jane
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Northwestern University at Chicago
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Garg, Parveen K; Arnold, Alice M; Hinckley Stukovsky, Karen D et al. (2016) Lipoprotein-Associated Phospholipase A2 and Incident Peripheral Arterial Disease in Older Adults: The Cardiovascular Health Study. Arterioscler Thromb Vasc Biol 36:750-6
Garg, Parveen K; McClelland, Robyn L; Jenny, Nancy S et al. (2015) Lipoprotein-associated phospholipase A2 and risk of incident cardiovascular disease in a multi-ethnic cohort: The multi ethnic study of atherosclerosis. Atherosclerosis 241:176-82
Garg, Parveen K; Biggs, Mary L; Carnethon, Mercedes et al. (2014) Metabolic syndrome and risk of incident peripheral artery disease: the cardiovascular health study. Hypertension 63:413-9
Forbang, Nketi I; McDermott, Mary M; Liao, Yihua et al. (2014) Associations of diabetes mellitus and other cardiovascular disease risk factors with decline in the ankle-brachial index. Vasc Med 19:465-72
Tesauro, Manfredi; Schinzari, Francesca; Adamo, Angelo et al. (2013) Effects of GLP-1 on forearm vasodilator function and glucose disposal during hyperinsulinemia in the metabolic syndrome. Diabetes Care 36:683-9
Gheorghiade, Mihai; Vaduganathan, Muthiah; Ambrosy, Andrew et al. (2013) Current management and future directions for the treatment of patients hospitalized for heart failure with low blood pressure. Heart Fail Rev 18:107-22
Jain, Atul; Liu, Kiang; Ferrucci, Luigi et al. (2013) Declining walking impairment questionnaire scores are associated with subsequent increased mortality in peripheral artery disease. J Am Coll Cardiol 61:1820-9
Gheorghiade, Mihai; Marti, Catherine N; Sabbah, Hani N et al. (2013) Soluble guanylate cyclase: a potential therapeutic target for heart failure. Heart Fail Rev 18:123-34
Ardehali, Hossein; Sabbah, Hani N; Burke, Michael A et al. (2012) Targeting myocardial substrate metabolism in heart failure: potential for new therapies. Eur J Heart Fail 14:120-9
Schinzari, Francesca; Tesauro, Manfredi; Rovella, Valentina et al. (2012) Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome. Am J Physiol Endocrinol Metab 303:E806-11

Showing the most recent 10 out of 18 publications