This revised Mentored Patient-Oriented Research Career Development Award (K23) application is a request for funding to support the training and research activities necessary for David J. Moser, Ph.D. to become an independent investigator in aging, vascular disease, and cognition. Atherosclerotic vascular disease (AVD) is the leading cause of mortality and morbidity in most industrialized nations and is a primary contributor to cognitive decline in the elderly. Despite this, there are very few longitudinal studies of AVD-related cognitive decline and the factors that are most predictive of this process. The identification of individuals who are at greatest risk for such decline will have significant implications for the development of interventions to prevent or attenuate this important health problem. This application includes an integrated and multidisciplinary program of training and research that utilizes the resources of the Center on Aging, the General Clinical Research Center, the Human Cardiovascular Physiology Laboratory, and the Departments of Psychiatry, Internal Medicine, Neurology, Biostatistics, Epidemiology, and Pharmacy at the University of Iowa. Trained in neuropsychology, the applicant now requires additional training in aging, cardiovascular and cerebrovascular physiology, longitudinal multivariate research, analysis of neuroimaging data, ethics, and grantwriting. This training and the proposed research project will allow the applicant to meet the following short-term scientific goals: 1 ) Determine whether elderly individuals with atherosclerotic vascular disease demonstrate inferior baseline neurocognitive performance and greater neurocognitive decline across time, as compared to healthy controls; and 2) Determine whether degree of endothelial dysfunction and/or other vascular illness-related variables can be used to identify subjects at greatest risk for neurocognitive decline. The training and data obtained during the K23 funding period will lay the foundation for the applicant's long-term scientific goal, which is to have an independent program of research aimed at preventing and/or reducing vascular-related cognitive decline.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23AG020649-01A1
Application #
6574630
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Wagster, Molly V
Project Start
2003-03-15
Project End
2008-02-28
Budget Start
2003-03-15
Budget End
2004-02-28
Support Year
1
Fiscal Year
2003
Total Cost
$155,609
Indirect Cost
Name
University of Iowa
Department
Psychiatry
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Stillman, Ashley N; Moser, David J; Fiedorowicz, Jess et al. (2013) Association of anxiety with resistance vessel dysfunction in human atherosclerosis. Psychosom Med 75:537-44
Bijanki, Kelly R; Stillman, Ashley N; Arndt, Stephan et al. (2013) White matter fractional anisotropy is inversely related to anxious symptoms in older adults with atherosclerosis. Int J Geriatr Psychiatry 28:1069-76
Rowe Bijanki, Kelly; Arndt, Stephan; Magnotta, Vincent A et al. (2013) Characterizing white matter health and organization in atherosclerotic vascular disease: a diffusion tensor imaging study. Psychiatry Res 214:389-94
Moser, David J; Boles Ponto, Laura L; Miller, Ivy N et al. (2012) Cerebral blood flow and neuropsychological functioning in elderly vascular disease patients. J Clin Exp Neuropsychol 34:220-5
Stillman, Ashley N; Rowe, Kelly C; Arndt, Stephan et al. (2012) Anxious symptoms and cognitive function in non-demented older adults: an inverse relationship. Int J Geriatr Psychiatry 27:792-8
Moore, Caitlin S; Miller, Ivy N; Andersen, Renee L et al. (2011) Gender differences in neuropsychological performance in individuals with atherosclerosis: impact of vascular function. J Clin Exp Neuropsychol 33:9-16
Hoth, Karin F; Poppas, Athena; Moser, David J et al. (2008) Cardiac dysfunction and cognition in older adults with heart failure. Cogn Behav Neurol 21:65-72
Moser, David J; Miller, Ivy N; Hoth, Karin F et al. (2008) Vascular smooth muscle function is associated with initiation and processing speed in patients with atherosclerotic vascular disease. J Int Neuropsychol Soc 14:535-41
Hoth, Karin F; Tate, David F; Poppas, Athena et al. (2007) Endothelial function and white matter hyperintensities in older adults with cardiovascular disease. Stroke 38:308-12
Fiedorowicz, Jess G; Moser, David J; Hynes, Stephanie M et al. (2007) LA allelic heterozygosity of the 5HTTLPR polymorphism is associated with higher cognitive function and lower interpersonal sensitivity. Psychiatr Genet 17:3-4

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