Glaucoma affects millions of Americans, but it is unclear how often impairment results from glaucoma. Understanding when impairment occurs is critical so that treatment can be tailored to achieve the ultimate goal of glaucoma treatment: death without visual disability. In this grant, we propose to define when, and in whom, glaucoma produces visual impairment. This will be studied through functional testing - in which task performance is directly observed and measured. Emphasis will be placed on defining conditions which decrease glaucoma-related impairment, and developing rehabilitative strategies to address such impairment. Training in the grant period will focus on learning how to test for functional impairment, perform complicated data analyses, and design and conduct clinical rehabilitative trials. Dr. Ramulu's long-term goals will be to use functional testing protocols to test the efficacy of rehabilitative strategies in the visually impaired, and to test for treatment efficacy in areas where standard measures of vision are poor surrogates for visual ability.

National Institute of Health (NIH)
National Eye Institute (NEI)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (ZEY1-VSN (01))
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Agarwal, Neeraj
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Johns Hopkins University
Schools of Medicine
United States
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Henrich, Claudia F; Ramulu, Pradeep Y; Akpek, Esen K (2014) Association of dry eye and inflammatory systemic diseases in a tertiary care-based sample. Cornea 33:819-25
Sengupta, Sabyasachi; van Landingham, Suzanne W; Solomon, Sharon D et al. (2014) Driving habits in older patients with central vision loss. Ophthalmology 121:727-32
van Landingham, Suzanne W; West, Sheila K; Akpek, Esen K et al. (2014) Impact of dry eye on reading in a population-based sample of the elderly: the Salisbury Eye Evaluation. Br J Ophthalmol 98:639-44
van Landingham, Suzanne W; Massof, Robert W; Chan, Emilie et al. (2014) Fear of falling in age-related macular degeneration. BMC Ophthalmol 14:10
Ramulu, Pradeep Y; Hochberg, Chad; Maul, Eugenio A et al. (2014) Glaucomatous visual field loss associated with less travel from home. Optom Vis Sci 91:187-93
Brown, Jamie C; Goldstein, Judith E; Chan, Tiffany L et al. (2014) Characterizing functional complaints in patients seeking outpatient low-vision services in the United States. Ophthalmology 121:1655-62.e1
Nguyen, Angeline M; van Landingham, Suzanne W; Massof, Robert W et al. (2014) Reading ability and reading engagement in older adults with glaucoma. Invest Ophthalmol Vis Sci 55:5284-90
Sherrod, Cheryl E; Vitale, Susan; Frick, Kevin D et al. (2014) Association of vision loss and work status in the United States. JAMA Ophthalmol 132:1239-42; quiz 1243-6
Mathews, Priya M; Ramulu, Pradeep Y; Friedman, David S et al. (2013) Evaluation of ocular surface disease in patients with glaucoma. Ophthalmology 120:2241-8
van Landingham, Suzanne W; Hochberg, Chad; Massof, Robert W et al. (2013) Driving patterns in older adults with glaucoma. BMC Ophthalmol 13:4

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