Glaucoma affects millions of Americans, but it is unclear how often impairment results from glaucoma. Understanding when impairment occurs is critical so that treatment can be tailored to achieve the ultimate goal of glaucoma treatment: death without visual disability. In this grant, we propose to define when, and in whom, glaucoma produces visual impairment. This will be studied through functional testing - in which task performance is directly observed and measured. Emphasis will be placed on defining conditions which decrease glaucoma-related impairment, and developing rehabilitative strategies to address such impairment. Training in the grant period will focus on learning how to test for functional impairment, perform complicated data analyses, and design and conduct clinical rehabilitative trials. Dr. Ramulu's long-term goals will be to use functional testing protocols to test the efficacy of rehabilitative strategies in the visually impaired, and to test for treatment efficacy in areas where standard measures of vision are poor surrogates for visual ability.

National Institute of Health (NIH)
National Eye Institute (NEI)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (ZEY1-VSN (01))
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Oversby, Steven
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Johns Hopkins University
Schools of Medicine
United States
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Mathews, Priya M; Ramulu, Pradeep Y; Swenor, Bonnielin S et al. (2017) Functional impairment of reading in patients with dry eye. Br J Ophthalmol 101:481-486
Swenor, Bonnielin K; Varadaraj, Varshini; Dave, Paulomi et al. (2017) Impact of the Ability to Divide Attention on Reading Performance in Glaucoma. Invest Ophthalmol Vis Sci 58:2456-2462
Willis, Jeffrey; Ramulu, Pradeep Y (2016) Poor Vision and Self-Reported Functional Difficulties among Recently Hospitalized Individuals in the United States. Ophthalmic Epidemiol 23:154-61
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Mathews, Priya M; Rubin, Gary S; McCloskey, Michael et al. (2015) Severity of vision loss interacts with word-specific features to impact out-loud reading in glaucoma. Invest Ophthalmol Vis Sci 56:1537-45
Akpek, Esen K; Cassard, Sandra D; Dunlap, Karen et al. (2015) Donor Corneal Transplantation vs Boston Type 1 Keratoprosthesis in Patients with Previous Graft Failures: A Retrospective Single Center Study (An American Ophthalmological Society Thesis). Trans Am Ophthalmol Soc 113:T3
Nguyen, Angeline M; van Landingham, Suzanne W; Massof, Robert W et al. (2014) Reading ability and reading engagement in older adults with glaucoma. Invest Ophthalmol Vis Sci 55:5284-90
van Landingham, Suzanne W; West, Sheila K; Akpek, Esen K et al. (2014) Impact of dry eye on reading in a population-based sample of the elderly: the Salisbury Eye Evaluation. Br J Ophthalmol 98:639-44

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