The K23 candidate is an assistant professor in the Department of Anesthesiology and Perioperative Medicine at Oregon Health &Science University (OHSU). This award is expected to help transition the focus of the candidate's research and to provide additional training in risk for chronic pain in children and adolescents. The candidate's career goals are to develop an independent research career related to identification and prevention of chronic pain in at risk youth. Specific objectives of the career development and research training plan are to obtain the necessary training to evaluate individual and family predictors of pain and somatic symptoms among at-risk youth, and to use laboratory pain reactivity data to test hypotheses about risk and resilience factors related to the development of chronic pain in children over time. The candidate proposes a five-year training program with faculty mentors from a strong anesthesiology department. Her sponsor is a very experienced pediatric pain researcher whose work has focused on understanding and treating the functional consequences of chronic pain in children. Additional mentors are experts in laboratory pain methods, health promotion and prevention in at risk youth, and longitudinal studies with children. OHSU is an ideal institution for this award owing to the breadth of resources available (e.g., Oregon Clinical and Translational Research Institute training opportunities). In addition to intensive mentoring by nationally renowned patient-oriented researchers, the career development plan includes coursework and didactic training in chronic pain treatment, laboratory pain methodology, grant writing skills, and research ethics. Other activities in the plan include research training in statistical methods and supervised experience in preparation of grant proposals for independent research support. The candidate's proposed research involves three specific aims.
The first aim i s to examine individual and parental correlates of pain and somatic symptoms, physical functioning, and psychological functioning within two groups: 1) children of adult caregivers with chronic pain, and 2) children of healthy parents without chronic pain.
The second aim i s to follow this cohort of children over a one-year period in adolescence to identify risk and protective factors that predict pain and somatic symptoms longitudinally and examine the role of child sex. Parental, psychological, and health-related risk factors will be examined.
The third aim i s to compare parental responses during laboratory pain tasks in the two groups to better understand the influence of parent behaviors on children's pain experiences. This innovative study utilizes clinical and laboratory pain assessment techniques to provide new information about an at risk population, and will inform the development of preventive interventions. The combined skill set and experience gained from the candidate's career development and research plan will provide the necessary early career support for the candidate to establish a successful independent research career focused on prevention and treatment of chronic pain and related disability among youth at risk for chronic pain. Public Health Relevance: Family history of chronic pain increases the risk for the development of chronic pain in children and adolescents. This study will identify risk and protective factors associated with pain reactivity and somatic symptoms in children who are living with an adult caregiver with chronic pain. The long-term goal is to prevent the development of adult chronic pain and related disability.

Public Health Relevance

Family history of chronic pain increases the risk for the development of chronic pain in children and adolescents. This study will identify risk and protective factors associated with pain reactivity and somatic symptoms in children who are living with an adult caregiver with chronic pain. The long-term goal is to prevent the development of adult chronic pain and related disability.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HD064705-03
Application #
8301731
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Haverkos, Lynne
Project Start
2010-06-20
Project End
2015-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
3
Fiscal Year
2012
Total Cost
$114,718
Indirect Cost
$8,498
Name
Oregon Health and Science University
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Wilson, Anna C; Fales, Jessica L (2015) Parenting in the context of chronic pain: a controlled study of parents with chronic pain. Clin J Pain 31:689-98
Fales, Jessica; Palermo, Tonya M; Law, Emily F et al. (2015) Sleep outcomes in youth with chronic pain participating in a randomized controlled trial of online cognitive-behavioral therapy for pain management. Behav Sleep Med 13:107-23
Birnie, Kathryn A; Caes, Line; Wilson, Anna C et al. (2014) A practical guide and perspectives on the use of experimental pain modalities with children and adolescents. Pain Manag 4:97-111
Wilson, Anna C; Moss, Ashley; Palermo, Tonya M et al. (2014) Parent pain and catastrophizing are associated with pain, somatic symptoms, and pain-related disability among early adolescents. J Pediatr Psychol 39:418-26
Wilson, Anna C; Holley, Amy Lewandowski; Palermo, Tonya M (2013) Applications of laboratory pain methodologies in research with children and adolescents: emerging research trends. Pain 154:1166-9
Duke, Danny C; Guion, Kim; Freeman, Kurt A et al. (2012) Commentary: health & behavior codes: great idea, questionable outcome. J Pediatr Psychol 37:491-5
Wilson, Anna C; Palermo, Tonya M (2012) Physical activity and function in adolescents with chronic pain: a controlled study using actigraphy. J Pain 13:121-30
Wilson, Anna C; Samuelson, Bethany; Palermo, Tonya M (2010) Obesity in children and adolescents with chronic pain: associations with pain and activity limitations. Clin J Pain 26:705-11