The candidate and principal investigator (PI) Geoffrey Tison, MD, MPH, is an Assistant Professor in the Divi- sion of Cardiology at the University of California, San Francisco. The long-term goal of the PI is to become an independent clinician-investigator with the training necessary to perform technology-leveraged clinical research to both investigate and facilitate cardiovascular disease prevention. Specifically, the training aims of this award will allow the PI to build upon his existing clinical research and data analysis skills to employ machine learning and other technology-based solutions, like mobile health tools, to advance heart failure prevention. The candi- date will complete coursework to develop his skills in machine learning, medical informatics, and clinical trial design and implementation, taking part in the UCSF Medical Informatics Training Program. To achieve these training goals, the candidate has assembled a mentoring team with extensive and complimentary expertise in clinical trials, epidemiology, and technology-enabled research (Dr. Jeff Olgin, the primary mentor, Dr. Mark Pletcher, Dr. Veronique Roger), biomedical/clinical informatics and novel data analysis (Dr. Atul Butte) and heart failure clinical and research expertise (Dr. Liviu Klein, Dr. Veronique Roger, Dr. John Spertus). This pro- ject seeks to take advantage of our current digital medical era to remotely capture individualized up-to-date patient data and predict dynamic risk, addressing the unmet need to improve remote heart failure management and decrease heart failure hospitalization. The project will test and develop tools to predict dynamic heart fail- ure risk based on real-time data measured in a free-living heart failure population?using a novel smartphone- based tool?and from patterns in up-to-date EHR data.
The specific aims are:
Aim 1 ?! Examine changes in functional status, measured by serial Self-Administered 6 Minute Walk Test, as a predictor of near-term HF hospitalization.
Aim 2 ?! Develop a ?dynamic? heart failure risk model that incorporates four types of up-to-date EHR data as it becomes available?including encounters, medication refills/changes, labs and vital signs. This research is expected to produce two validated methods to estimate dynamic, up-to-date heart failure risk to enable the provision of earlier, more effective outpatient interventions that decrease hospitalization. This con- tribution has the potential to improve remote management for heart failure patients, while shifting the clinical care paradigm to utilize dynamic, longitudinal and free-living data for clinical decision-making. This award will directly enable a future R01-level randomized pragmatic clinical to trial test the hypothesis that delivery of up- to-date risk information to outpatient clinicians can decrease future HF hospitalizations. This award will provide the PI with a unique combination of skills: a strong clinical background, a rigorous clinical research foundation, advanced analytic skills in machine learning and fluency to utilize health-related technologies to derive insights and deliver preventive interventions.

Public Health Relevance

Heart failure is the number one cause of hospital readmission in those over 65 years of age and the current standard-of-care of weight self-monitoring is inadequate to predict exacerbation. This project aims to improve the monitoring of heart failure disease progression through the use of real-time, up-to-date data obtained both from a smartphone-based tool and from the electronic health record. The goal is to develop a low-risk, clinically validated method to estimate dynamic heart failure risk to enable the provision of earlier, more effective outpatient interventions that decrease hospitalization.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HL135274-02
Application #
9625645
Study Section
NHLBI Mentored Patient-Oriented Research Review Committee (MPOR)
Program Officer
Scott, Jane
Project Start
2018-01-15
Project End
2022-11-30
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118