This proposal requests continued NIA funding for the Midcareer Investigator Award in Patient- Oriented Research (K24) to Dr. Kristine Yaffe. The overarching aims of this K24 renewal application are three-fold: 1) To perform rigorous patient-based research studies in a new direction aimed at the identification of the predictors of cognitive aging and structural brain integrity across the lifecourse among biracial adults, 2) To use the applicant's research as a platform for the mentorship of patient-oriented researchers in the epidemiology of cognitive aging and 3) To enable the applicant to pursue new research directions and to continue to support her development as an internationally recognized mentor for trainees from a wide range of disciplines interested in cognitive aging. During the first 5 years of support provided by the K24 award, Dr. Yaffe has been both a very productive mentor and independently funded investigator. During this period, she has obtained eight patient-oriented research grants (3 R01s, 2 Project Cores on Program Projects from NIH, an Investigator-Initiated Research Grant from the Alzheimer's Association, a Department of Defense grant and an American Health Foundation grant). Over the initial K24 project period from 2007 to 2012, Dr. Yaffe has served as primary or secondary mentor to 19 trainees in a wide range of disciplines and at various levels of training. Dr. Yaffe's long-term goals are to become an international leader in aging research, to contribute substantially to our understanding and approaches to the treatment and prevention of cognitive impairment and to mentor the next generation of investigators interested in the epidemiology of cognitive aging. This one-time renewal of a mid-career development award will help her to reach these goals.

Public Health Relevance

The identification of who is at risk for cognitive impairment associated with aging remains one of the most important goals of our time. By increasing our understanding of cognitive function in midlife and identifying earlier risk factors extending from early adulthood, it may be possible to intervene to prevent dementia and maintain healthy brain aging. In addition, knowledge of the lifecourse antecedents, including the timing and cumulative risk of exposure, of cognitive aging could inform the nature of these interventions.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Wagster, Molly V
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University of California San Francisco
Schools of Medicine
San Francisco
United States
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Peltz, Carrie B; Gardner, Raquel C; Kenney, Kimbra et al. (2017) Neurobehavioral Characteristics of Older Veterans With Remote Traumatic Brain Injury. J Head Trauma Rehabil 32:E8-E15
Kaup, Allison R; Yaffe, Kristine (2017) Reassuring News About Football and Cognitive Decline?: Not So Fast. JAMA Neurol 74:898-899
McEvoy, Claire T; Guyer, Heidi; Langa, Kenneth M et al. (2017) Neuroprotective Diets Are Associated with Better Cognitive Function: The Health and Retirement Study. J Am Geriatr Soc 65:1857-1862
Zeki Al Hazzouri, Adina; Elfassy, Tali; Sidney, Stephen et al. (2017) Sustained Economic Hardship and Cognitive Function: The Coronary Artery Risk Development in Young Adults Study. Am J Prev Med 52:1-9
Kaup, Allison R; Peltz, Carrie; Kenney, Kimbra et al. (2017) Neuropsychological Profile of Lifetime Traumatic Brain Injury in Older Veterans. J Int Neuropsychol Soc 23:56-64
Byers, Amy L; Lai, Amy X; Arean, Patricia et al. (2016) Mental Health Service Use Across the Life Course Among Adults With Psychiatric Disorders and Prior Suicidal Behavior. Psychiatr Serv 67:452-5
Kaup, Allison R; Byers, Amy L; Falvey, Cherie et al. (2016) Trajectories of Depressive Symptoms in Older Adults and Risk of Dementia. JAMA Psychiatry 73:525-31
Stone, Katie L; Blackwell, Terri L; Ancoli-Israel, Sonia et al. (2016) Sleep Disordered Breathing and Risk of Stroke in Older Community-Dwelling Men. Sleep 39:531-40
Hoang, Tina D; Reis, Jared; Zhu, Na et al. (2016) Effect of Early Adult Patterns of Physical Activity and Television Viewing on Midlife Cognitive Function. JAMA Psychiatry 73:73-9
Yaffe, Kristine; Nasrallah, Ilya; Hoang, Tina D et al. (2016) Sleep Duration and White Matter Quality in Middle-Aged Adults. Sleep 39:1743-7

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