This grant is being requested to support Dr. Howard Rosen, a behavioral neurologist whose research has focused on early recognition, better characterization and longitudinal tracking of atypical neurodegenerative diseases, in particular frontotemporal lobar degeneration (FTLD), using clinical and experimental behavioral assessment and imaging. Dr. Rosen has a longstanding interest in mentoring. The goals of this proposal are 1) to support time for Dr. Rosen to provide mentoring to a growing number of clinical researchers, 2) to support time for him to augment his skills as an investigator and 3) to increase his ability to conduct patient oriented research (POR) and to impart these skills to his mentees. To accomplish these goals he will augment his skills in statistical analysis, increase his efforts in self-development as a mentor and develop a more formal mentoring program. In addition, this grant will be particularly instrumental in supporting Dr. Rosen's new goals, which include improving his understanding of geriatric psychiatric assessment, introducing these approaches into his research and reaching out to more trainees interested in psychiatric symptoms. Training for both Dr. Rosen and his mentees will be accomplished through selected coursework and research activities including data analysis and manuscript preparation, using the data from Dr. Rosen's ongoing projects, including the Frontotemporal Lobar Degeneration Neuroimaging Initiative, and an ongoing project to study the cognitive and emotional basis of impaired self-awareness in dementia. Because of his experience in both multimodal brain imaging and psychophysiological and behavioral methodology from emotions research, Dr. Rosen has unique expertise that can benefit trainees with neurology, psychiatry and psychology backgrounds. In addition, Dr. Rosen is proposing a new project, which will add the Structured Clinical Interview for DSM (SCID) to the clinical assessment of members of families affected by mutations that cause FTLD (f-FTLD).
The aims of the project are to quantify the frequency of traditional psychiatric syndromes in early f-FTLD, and to assess value of psychiatric diagnosis in predicting the rate of cortical thinning over one year. The study will provide better characterization of the early clinical presentation of f-FTLD and give guidance about the psychiatric symptoms that may precede the development of sporadic FTLD, which can then be investigated in future studies.
The proposed grant would support the research and mentoring activities of Dr. Howard Rosen, a behavioral neurologist whose research focuses on early recognition, better characterization and longitudinal tracking of atypical neurodegenerative dementias, in particular frontotemporal lobar degeneration (FTLD). Currently, there are no specific treatments for most atypical dementias, and no well-established signs indicating when these diseases might be developing. Multimodal brain imaging and novel clinical assessments will be required to make inroads on recognition and treatment of these devastating diseases, and these techniques are the focus of the proposal.
|Ljubenkov, Peter A; Staffaroni, Adam M; Rojas, Julio C et al. (2018) Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory. Ann Clin Transl Neurol 5:1250-1263|
|Elahi, Fanny M; Marx, Gabe; Cobigo, Yann et al. (2017) Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease. Neuroimage Clin 16:595-603|
|Sturm, Virginia E; Perry, David C; Wood, Kristie et al. (2017) Prosocial deficits in behavioral variant frontotemporal dementia relate to reward network atrophy. Brain Behav 7:e00807|
|Bonham, Luke W; Sirkis, Daniel W; Fan, Jia et al. (2017) Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease. Neurocase 23:65-69|
|Ferrari, Raffaele; Wang, Yunpeng; Vandrovcova, Jana et al. (2017) Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry 88:152-164|
|Staffaroni, Adam M; Elahi, Fanny M; McDermott, Dana et al. (2017) Neuroimaging in Dementia. Semin Neurol 37:510-537|
|Scherling, Carole S; Zakrzewski, Jessica; Datta, Samir et al. (2017) Mistakes, Too Few to Mention? Impaired Self-conscious Emotional Processing of Errors in the Behavioral Variant of Frontotemporal Dementia. Front Behav Neurosci 11:189|
|Perry, David C; Brown, Jesse A; Possin, Katherine L et al. (2017) Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain 140:3329-3345|
|Binney, Richard J; Pankov, Aleksandr; Marx, Gabriel et al. (2017) Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration. Brain Behav 7:e00675|
|Yokoyama, Jennifer S; Karch, Celeste M; Fan, Chun C et al. (2017) Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathol 133:825-837|
Showing the most recent 10 out of 51 publications