This is the first renewal application for a K24 award for Dr. Howard Rosen, a behavioral neurologist at the University of California, San Francisco. Dr. Rosen?s research focuses on early recognition and longitudinal tracking of atypical neurodegenerative diseases, in particular frontotemporal dementia (FTD). The work takes place at the UCSF Memory and Aging Center, a large multidisciplinary group dedicated to research, care and education in neurodegenerative diseases. In the first cycle of this project, Dr. Rosen served as a mentor for 21 individuals at various stages of training and accomplished his goals of expanding his research on familial forms of FTD. He helped to implement new strategies for diagnosis of FTD through collaboration with the UCSF Department of Psychiatry. Dr. Rosen also expanded the reach of his educational expertise by leading development of the educational curriculum for a new training program called the Global Brain Health Institute, the mission of which is to address worldwide threats to brain health through training of professionals from a variety of disciplines. With continued K24 funding, Dr. Rosen will continue his leadership of research and training at the MAC, focusing on improving methods for measuring change in FTD for use in clinical trials and expanding collaboration with UCSF Psychiatry. He will improve his expertise as an investigator through selective coursework and collaboration with expert colleagues at UCSF.
This project would support continued funding for Dr. Howard Rosen, a behavioral neurologist in the Department of Neurology at the University of California, San Francisco. Dr. Rosen conducts patient-oriented research on early and accurate diagnosis and longitudinal tracking of diseases that cause dementia, in particular frontotemporal dementia. He is a committed teacher and funds from this project will allow him to continue mentoring young trainees whose goals is to pursue research in neurodegenerative disease.
|Ljubenkov, Peter A; Staffaroni, Adam M; Rojas, Julio C et al. (2018) Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory. Ann Clin Transl Neurol 5:1250-1263|
|Bonham, Luke W; Sirkis, Daniel W; Fan, Jia et al. (2017) Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease. Neurocase 23:65-69|
|Ferrari, Raffaele; Wang, Yunpeng; Vandrovcova, Jana et al. (2017) Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry 88:152-164|
|Staffaroni, Adam M; Elahi, Fanny M; McDermott, Dana et al. (2017) Neuroimaging in Dementia. Semin Neurol 37:510-537|
|Scherling, Carole S; Zakrzewski, Jessica; Datta, Samir et al. (2017) Mistakes, Too Few to Mention? Impaired Self-conscious Emotional Processing of Errors in the Behavioral Variant of Frontotemporal Dementia. Front Behav Neurosci 11:189|
|Perry, David C; Brown, Jesse A; Possin, Katherine L et al. (2017) Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain 140:3329-3345|
|Binney, Richard J; Pankov, Aleksandr; Marx, Gabriel et al. (2017) Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration. Brain Behav 7:e00675|
|Yokoyama, Jennifer S; Karch, Celeste M; Fan, Chun C et al. (2017) Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathol 133:825-837|
|Spina, Salvatore; Schonhaut, Daniel R; Boeve, Bradley F et al. (2017) Frontotemporal dementia with the V337M MAPT mutation: Tau-PET and pathology correlations. Neurology 88:758-766|
|Perry, David C; Datta, Samir; Sturm, Virginia E et al. (2017) Reward deficits in behavioural variant frontotemporal dementia include insensitivity to negative stimuli. Brain 140:3346-3356|
Showing the most recent 10 out of 51 publications