Osteoporosis is a significant concern for both older men and women. Recent studies suggest skeletal biomarkers might provide important information about the biologic causes of osteoporosis and may be useful to predict fracture alone or when combined with other risk factors. To extend his ongoing NIH-funded work on biomarkers and skeletal fragility, Dr. Douglas Bauer, Professor of Medicine, Epidemiology &Biostatistics at the University of California, San Francisco, is requesting a renewal of his K24 Midcareer Investigator Award in Patient-Oriented Research with the scientific goals of developing new and clinically useful proteomic biomarkers using data from a well characterized longitudinal cohort of older men (MrOS). Taking advantage of ongoing assessments for fracture and recent funding for proteomic measurements in serum collected at baseline, this study will explore the prospective relationship between proteomic profile and incident vertebral fracture in 3000 MrOS participants. Using these and other data from multiple large studies available through his longstanding affiliation with the San Francisco Coordinating Center, Dr. Bauer will continue to mentor young investigators who are interested in clinical research, particularly residents. With the initial K24 award Dr. Bauer mentored residents and fellows who are now pursuing additional research training and academic careers. In conjunction with the UCSF Clinical and Translational Science Institute, during the initial K24 award he also developed and directed a new comprehensive Resident Research Program. The goal of this novel program is to promote clinical research careers by providing residents with formal instruction in research methods, pilot funding and opportunities to participate in mentored research projects. The continuation of this K24 award is critical to protect Dr. Bauer's time and allow him to continue to make significant contributions towards patient-oriented research related to biomarkers and skeletal fragility and to expand his successful mentoring program.

Public Health Relevance

Osteoporotic fractures are an important public health concern. This project will build on previous work by the applicant to understand the biologic factors associated with osteoporotic fractures, particularly in men. The project will also allow the application to continue and expand his successful mentoring program for junior investigators who are interested in patient-oriented research.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Chen, Faye H
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Bauer, Douglas C; Black, Dennis M; Bouxsein, Mary L et al. (2018) Treatment-Related Changes in Bone Turnover and Fracture Risk Reduction in Clinical Trials of Anti-Resorptive Drugs: A Meta-Regression. J Bone Miner Res 33:634-642
Chaffee, Benjamin W; Couch, Elizabeth T; Gansky, Stuart A (2018) Adolescents' smokeless tobacco susceptibility by perceived professional baseball players' use. J Public Health Dent 78:5-8
Moazed, Farzad; Hendrickson, Carolyn; Nelson, Mary et al. (2018) Platelet aggregation after blunt trauma is associated with the acute respiratory distress syndrome and altered by cigarette smoke exposure. J Trauma Acute Care Surg 84:365-371
Segna, D; Bauer, D C; Feller, M et al. (2018) Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts. J Intern Med 283:56-72
Stott, David J; Rodondi, Nicolas; Kearney, Patricia M et al. (2017) Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. N Engl J Med 376:2534-2544
Aubert, Carole E; Floriani, Carmen; Bauer, Douglas C et al. (2017) Thyroid Function Tests in the Reference Range and Fracture: Individual Participant Analysis of Prospective Cohorts. J Clin Endocrinol Metab 102:2719-2728
LeBlanc, Erin S; Rosales, A Gabriela; Black, Dennis M et al. (2017) Evaluating Atypical Features of Femur Fractures: How Change in Radiological Criteria Influenced Incidence and Demography of Atypical Femur Fractures in a Community Setting. J Bone Miner Res 32:2304-2314
Aubert, Carole E; Bauer, Douglas C; da Costa, Bruno R et al. (2017) The association between subclinical thyroid dysfunction and dementia: The Health, Aging and Body Composition (Health ABC) Study. Clin Endocrinol (Oxf) 87:617-626
Chaffee, Benjamin W; Featherstone, John D B; Zhan, Ling (2017) Pediatric Caries Risk Assessment as a Predictor of Caries Outcomes. Pediatr Dent 39:219-232
Dzeng, Elizabeth (2017) Navigating the Liminal State Between Life and Death: Clinician Moral Distress and Uncertainty Regarding New Life-Sustaining Technologies. Am J Bioeth 17:22-25

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