Douglas C. Bauer, MD is an Associate Professor of Medicine, and Epidemiology and Biostatistics at the University of California, San Francisco, with an established track record as a researcher, educator, and clinician. After completing fellowship training in clinical epidemiology in 1992, Dr Bauer undertook a 3 year mentored career development award with Dr. Steven Cummings. He is currently Director of Research for the Division of General Internal Medicine, and is a core faculty member of the UCSF Coordinating Center (UCSF CC). The candidate proposes building a program of patient-oriented research focused on the use of biomarkers in musculoskeletal and aging research. The objectives of the program are to promote patient-oriented research at UCSF among medical residents, fellows, and junior faculty, and to provide junior investigators with opportunities to better understand biomarker methodology and utilize biomarkers in their research. Using the many clinical research training resources available at UCSF and several large osteoporosis clinical trial databases available to Dr. Bauer through the UCSF CC, the overall aims of this program are: 1) to mentor medical residents, clinical research fellows, and junior faculty to conduct patient-oriented research; 2) to provide expertise and opportunities for mentees who wish to utilize biomarkers in patient-oriented musculoskeletal research and 3) to advance our understanding of biomarkers in osteoporosis.
The specific aims of Dr. Bauer's research plan are: 1) To determine differences in the anti-fracture efficacy of several anti-resorptive treatments for osteoporosis defined by baseline levels of selected biomarkers, including estradiol and markers of bone turnover; 2) To compare the adequacy of change in biochemical markers of bone turnover to serve as a surrogate for fracture outcomes in clinical trials of alendronate, raloxifene, and estrogen-progestin; and 3) To compare the degree of mediation of the anti-fracture effect of several osteoporosis treatments, including alendronate, raloxifene, and estrogen-progestins, by change in BMD as well as change in biochemical markers of bone turnover. Funding of this K24 will allow Dr. Bauer to reduce his clinical and administrative responsibilities, and focus his efforts on promoting and teaching patient-oriented research.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Special Emphasis Panel (ZAR1-TLB-D (O1))
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Mcgowan, Joan A
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Bauer, Douglas C; Black, Dennis M; Bouxsein, Mary L et al. (2018) Treatment-Related Changes in Bone Turnover and Fracture Risk Reduction in Clinical Trials of Anti-Resorptive Drugs: A Meta-Regression. J Bone Miner Res 33:634-642
Chaffee, Benjamin W; Couch, Elizabeth T; Gansky, Stuart A (2018) Adolescents' smokeless tobacco susceptibility by perceived professional baseball players' use. J Public Health Dent 78:5-8
Moazed, Farzad; Hendrickson, Carolyn; Nelson, Mary et al. (2018) Platelet aggregation after blunt trauma is associated with the acute respiratory distress syndrome and altered by cigarette smoke exposure. J Trauma Acute Care Surg 84:365-371
Segna, D; Bauer, D C; Feller, M et al. (2018) Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts. J Intern Med 283:56-72
LeBlanc, Erin S; Rosales, A Gabriela; Black, Dennis M et al. (2017) Evaluating Atypical Features of Femur Fractures: How Change in Radiological Criteria Influenced Incidence and Demography of Atypical Femur Fractures in a Community Setting. J Bone Miner Res 32:2304-2314
Aubert, Carole E; Bauer, Douglas C; da Costa, Bruno R et al. (2017) The association between subclinical thyroid dysfunction and dementia: The Health, Aging and Body Composition (Health ABC) Study. Clin Endocrinol (Oxf) 87:617-626
Chaffee, Benjamin W; Featherstone, John D B; Zhan, Ling (2017) Pediatric Caries Risk Assessment as a Predictor of Caries Outcomes. Pediatr Dent 39:219-232
Dzeng, Elizabeth (2017) Navigating the Liminal State Between Life and Death: Clinician Moral Distress and Uncertainty Regarding New Life-Sustaining Technologies. Am J Bioeth 17:22-25
Ley, Brett; Newton, Chad A; Arnould, Isabel et al. (2017) The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis: an observational cohort-control study. Lancet Respir Med 5:639-647
Chaffee, Benjamin W; Couch, Elizabeth T; Gansky, Stuart A (2017) Trends in characteristics and multi-product use among adolescents who use electronic cigarettes, United States 2011-2015. PLoS One 12:e0177073

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