This is a new application for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Sean Mackey, is a physician-scientist, Associate Professor and Division Chief of Pain Medicine at Stanford University. Over the past 5 years, Dr. Mackey has developed expertise in several advanced neuroimaging and psychophysical techniques and applied these to the study of pain. This has led to his developing an independent patient-oriented research (POR) career. This independence is demonstrated by his receiving three independent research awards that use MR techniques to investigate the central neural correlates of pain in patients with chronic pain;he is PI on all three of these awards (one each by NIDA, NINDS and NIDDK). Dr. Mackey has a 10 year history of mentoring junior clinician scientists, postdoctoral fellows, medical students, and graduate students - all performing POR. In addition, Dr. Mackey has active collaborations with many NIH-funded investigators in the area of pain research and its intersection with substance abuse. The current application requests funding (50% salary) for 5 years. This funding will guarantee that the candidate will have at least 75% protected time to conduct his ongoing research and to continue to mentor clinician scientists performing POR. As Dr. Mackey is the Division Chief of Pain Medicine, this award will free time now devoted to administrative and clinical responsibilities to focus more on his research and mentoring activities over the next 5 years. In addition to working on the three ongoing NIH-funded projects, the candidate will obtain additional training in advanced multimodal MR collection and analysis methods (machine learning algorithms, diffusion tensor imaging, genomic imaging) and functional near-infrared spectroscopy imaging. This will allow the candidate to develop new approaches to characterize the central neuroplastic changes that occur in chronic pain and its link with addiction. Given the outstanding resources and collaborations at Stanford, these novel projects are expected to be either renewed or to lead to new directions in pain and substance abuse research, and significantly contribute to our scientific understanding of these disabling conditions.

Public Health Relevance

Chronic pain has a tremendous impact on the individual and society as a whole. We need better understanding of the mechanisms leading to the generation and maintenance of chronic pain conditions. This K24 award will permit the PI to increase his efforts in mentoring junior investigators in patient-oriented research, and to conduct research to find solutions to alleviate the suffering of patients with chronic pain.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1-GXM-A (11))
Program Officer
Lin, Yu
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Stanford University
Schools of Medicine
United States
Zip Code
Hah, Jennifer M; Mackey, Sean; Barelka, Peter L et al. (2014) Self-loathing aspects of depression reduce postoperative opioid cessation rate. Pain Med 15:954-64
Bagarinao, Epifanio; Johnson, Kevin A; Martucci, Katherine T et al. (2014) Preliminary structural MRI based brain classification of chronic pelvic pain: A MAPP network study. Pain 155:2502-9
Barad, Meredith J; Ueno, Takefumi; Younger, Jarred et al. (2014) Complex regional pain syndrome is associated with structural abnormalities in pain-related regions of the human brain. J Pain 15:197-203
Stoeckel, L E; Garrison, K A; Ghosh, S et al. (2014) Optimizing real time fMRI neurofeedback for therapeutic discovery and development. Neuroimage Clin 5:245-55
Kong, Jiang-Ti; Johnson, Kevin A; Balise, Raymond R et al. (2013) Test-retest reliability of thermal temporal summation using an individualized protocol. J Pain 14:79-88
Bruehl, Stephen; Apkarian, A Vania; Ballantyne, Jane C et al. (2013) Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. J Pain 14:103-13
Mackey, Sean; Carroll, Ian; Emir, Birol et al. (2012) Sensory pain qualities in neuropathic pain. J Pain 13:58-63
Brown, Justin E; Chatterjee, Neil; Younger, Jarred et al. (2011) Towards a physiology-based measure of pain: patterns of human brain activity distinguish painful from non-painful thermal stimulation. PLoS One 6:e24124
Lawrence, Jane M; Hoeft, Fumiko; Sheau, Kristen E et al. (2011) Strategy-dependent dissociation of the neural correlates involved in pain modulation. Anesthesiology 115:844-51
Younger, Jarred W; Chu, Larry F; D'Arcy, Nicole T et al. (2011) Prescription opioid analgesics rapidly change the human brain. Pain 152:1803-10

Showing the most recent 10 out of 13 publications