This is a new application for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Sean Mackey, is a physician-scientist, Associate Professor and Division Chief of Pain Medicine at Stanford University. Over the past 5 years, Dr. Mackey has developed expertise in several advanced neuroimaging and psychophysical techniques and applied these to the study of pain. This has led to his developing an independent patient-oriented research (POR) career. This independence is demonstrated by his receiving three independent research awards that use MR techniques to investigate the central neural correlates of pain in patients with chronic pain;he is PI on all three of these awards (one each by NIDA, NINDS and NIDDK). Dr. Mackey has a 10 year history of mentoring junior clinician scientists, postdoctoral fellows, medical students, and graduate students - all performing POR. In addition, Dr. Mackey has active collaborations with many NIH-funded investigators in the area of pain research and its intersection with substance abuse. The current application requests funding (50% salary) for 5 years. This funding will guarantee that the candidate will have at least 75% protected time to conduct his ongoing research and to continue to mentor clinician scientists performing POR. As Dr. Mackey is the Division Chief of Pain Medicine, this award will free time now devoted to administrative and clinical responsibilities to focus more on his research and mentoring activities over the next 5 years. In addition to working on the three ongoing NIH-funded projects, the candidate will obtain additional training in advanced multimodal MR collection and analysis methods (machine learning algorithms, diffusion tensor imaging, genomic imaging) and functional near-infrared spectroscopy imaging. This will allow the candidate to develop new approaches to characterize the central neuroplastic changes that occur in chronic pain and its link with addiction. Given the outstanding resources and collaborations at Stanford, these novel projects are expected to be either renewed or to lead to new directions in pain and substance abuse research, and significantly contribute to our scientific understanding of these disabling conditions.

Public Health Relevance

Chronic pain has a tremendous impact on the individual and society as a whole. We need better understanding of the mechanisms leading to the generation and maintenance of chronic pain conditions. This K24 award will permit the PI to increase his efforts in mentoring junior investigators in patient-oriented research, and to conduct research to find solutions to alleviate the suffering of patients with chronic pain.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DA029262-04
Application #
8450281
Study Section
Special Emphasis Panel (ZDA1-GXM-A (11))
Program Officer
Lin, Yu
Project Start
2010-05-01
Project End
2015-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
4
Fiscal Year
2013
Total Cost
$202,100
Indirect Cost
$14,970
Name
Stanford University
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Karayannis, Nicholas V; Sturgeon, John A; Chih-Kao, Ming et al. (2017) Pain interference and physical function demonstrate poor longitudinal association in people living with pain: a PROMIS investigation. Pain 158:1063-1068
Jarrahi, Behnaz; Martucci, Katherine T; Nilakantan, Aneesha S et al. (2017) Investigating the BOLD spectral power of the intrinsic connectivity networks in fibromyalgia patients: A resting-state fMRI study. Conf Proc IEEE Eng Med Biol Soc 2017:497-500
Hah, Jennifer M; Sturgeon, John A; Zocca, Jennifer et al. (2017) Factors associated with prescription opioid misuse in a cross-sectional cohort of patients with chronic non-cancer pain. J Pain Res 10:979-987
Carriere, Junie S; Martel, Marc-Olivier; Kao, Ming-Chih et al. (2017) Pain behavior mediates the relationship between perceived injustice and opioid prescription for chronic pain: a Collaborative Health Outcomes Information Registry study. J Pain Res 10:557-566
Hah, Jennifer; Mackey, Sean C; Schmidt, Peter et al. (2017) Effect of Perioperative Gabapentin on Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort: A Randomized Clinical Trial. JAMA Surg :
Darnall, Beth D; Sturgeon, John A; Cook, Karon F et al. (2017) Development and Validation of a Daily Pain Catastrophizing Scale. J Pain 18:1139-1149
Sturgeon, John A; Hah, Jennifer M; Sharifzadeh, Yasamin et al. (2017) Predictors of Daily Pain Medication Use in Individuals with Recurrent Back Pain. Int J Behav Med :
Taub, Chloe J; Sturgeon, John A; Johnson, Kevin A et al. (2017) Effects of a Pain Catastrophizing Induction on Sensory Testing in Women with Chronic Low Back Pain: A Pilot Study. Pain Res Manag 2017:7892494
Feinstein, Amanda B; Sturgeon, John A; Darnall, Beth D et al. (2017) The Effect of Pain Catastrophizing on Outcomes: A Developmental Perspective Across Children, Adolescents, and Young Adults With Chronic Pain. J Pain 18:144-154
Sturgeon, John A; Ziadni, Maisa S; Trost, Zina et al. (2017) Pain catastrophizing, perceived injustice, and pain intensity impair life satisfaction through differential patterns of physical and psychological disruption. Scand J Pain 17:390-396

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