The primary goals of this K24 competing renewal application are to allow Sean Mackey, M.D., Ph.D. to 1) continue to devote near full time effort to his program of pain and prescription opioid research; and 2) provide high-quality and intensive mentorship of early-career investigators in patient-oriented research (P0R). A K24 renewal will continue to provide Dr. Mackey with the critical protected time for POR and mentoring that would otherwise be spent on administrative and clinical responsibilities. Dr. Mackey is the Redlich Professor and Division Chief of Pain Medicine at Stanford University. Since receiving a K24 award Dr. Mackey has accomplished the major goals of his original application and much more. Dr. Mackey's research plan for this K24 renewal application includes work as a P01 PD to investigate mechanisms of chronic low back pain (CLBP) and four therapies; characterizing the effects of opioids on brain structure in patients with CLBP; expanding his work in neuroimaging based biomarkers (Co-I on R01); continuing role in the NIDDK Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain network; further development, implementation and dissemination of the Stanford-NIH based partnership for an open-source, free health registry (PI). Dr. Mackey's mentoring plan includes training his mentees in: 1) designing and implementing pain research studies; 2) preparing scientific papers and presentations; 3) writing successful grant applications; 4) responsible conduct of research; and 5) successful navigation of the academic process to achieve scientific independence. This mentoring plan will be applied to his direct mentees as well as those he oversees as the PD for his NIDA T32 Interdisciplinary Research Training in Pain and Substance Use Disorders. Dr. Mackey will accomplish this through a combination of role modeling, individual and group meetings, collaborative mentoring, and integration with Stanford's Clinical and Translational Science Award (CTSA) mentoring program. Dr. Mackey's career development plan includes further training in machine learning approaches for neuroimaging analysis as well as for his health registry; multimodal MRI collection and analysis methods; analysis of large data sets and longitudinal data. With the outstanding resources and collaborations at Stanford and novel projects, the ongoing projects are expected to be either renewed or lead to new directions in pain and substance use research and significantly contribute to our scientific understanding of these disabling conditions. Further, these projects and Dr. Mackey's mentorship will support the need to train the next generation of investigators conducting important pain and substance abuse POR.

Public Health Relevance

Chronic pain has a tremendous impact on the individual and society as a whole. We need better understanding of the mechanisms involved with the generation and maintenance of chronic pain conditions. This K24 award will permit the PI to continue and expand his efforts in mentoring junior investigators in patient-oriented research and to conduct research to find solutions to alleviate the suffering of patients with chronic pain.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Study Section
Somatosensory and Chemosensory Systems Study Section (SCS)
Program Officer
Lin, Yu
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Stanford University
Schools of Medicine
United States
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Martucci, Katherine T; Weber 2nd, Kenneth A; Mackey, Sean C (2018) Altered Cervical Spinal Cord Resting State Activity in Fibromyalgia. Arthritis Rheumatol :
Carriere, Junie S; Sturgeon, John A; Yakobov, Esther et al. (2018) The Impact of Perceived Injustice on Pain-related Outcomes: A Combined Model Examining the Mediating Roles of Pain Acceptance and Anger in a Chronic Pain Sample. Clin J Pain 34:739-747
Martucci, Katherine T; Borg, Nicholas; MacNiven, Kelly H et al. (2018) Altered prefrontal correlates of monetary anticipation and outcome in chronic pain. Pain 159:1494-1507
Gaertner, Mark; Kong, Jiang-Ti; Scherrer, Kristen H et al. (2018) Advancing Transcranial Magnetic Stimulation Methods for Complex Regional Pain Syndrome: An Open-Label Study of Paired Theta Burst and High-Frequency Stimulation. Neuromodulation 21:409-416
Weber 2nd, Kenneth A; Sentis, Amy I; Bernadel-Huey, Olivia N et al. (2018) Thermal Stimulation Alters Cervical Spinal Cord Functional Connectivity in Humans. Neuroscience 369:40-50
Sturgeon, John A; Hah, Jennifer M; Sharifzadeh, Yasamin et al. (2018) Predictors of Daily Pain Medication Use in Individuals with Recurrent Back Pain. Int J Behav Med 25:252-258
Martucci, Katherine T; Mackey, Sean C (2018) Neuroimaging of Pain: Human Evidence and Clinical Relevance of Central Nervous System Processes and Modulation. Anesthesiology 128:1241-1254
Hah, Jennifer; Mackey, Sean C; Schmidt, Peter et al. (2018) Effect of Perioperative Gabapentin on Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort: A Randomized Clinical Trial. JAMA Surg 153:303-311
Sturgeon, John A; Ziadni, Maisa S; Trost, Zina et al. (2017) Pain catastrophizing, perceived injustice, and pain intensity impair life satisfaction through differential patterns of physical and psychological disruption. Scand J Pain 17:390-396
Karayannis, Nicholas V; Sturgeon, John A; Chih-Kao, Ming et al. (2017) Pain interference and physical function demonstrate poor longitudinal association in people living with pain: a PROMIS investigation. Pain 158:1063-1068

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