This is a proposal for a midcareer investigator award in patient-oriented research for Dr. Gregory Lucas, Associate Professor at the Johns Hopkins School of Medicine. Dr. Lucas is medically trained as an infectious diseases specialist and he completed a PhD in clinical investigation at the Bloomberg School of Public Health in 2004. His research career focuses on interventions to improve access to care and outcomes among injection drug users (IDUs), and on chronic kidney disease, a common HIV-related comorbidity that is especially prevalent among IDUs. Injection drug use remains an important mode of HIV transmission worldwide, is a consistent barrier to optimal HIV treatment outcomes, and is a risk factor for medical comorbidity and early mortality. The objective of this proposal is to support a program for mentoring junior investigators and for fostering innovative research. This grant discusses two active research platforms that will serve as a framework for engaging trainees in HIV-related patient-focused research. First, Dr. Lucas is PI of kidney disease cohort designed to assess the roles of HIV, hepatitis C, and active drug use on kidney and cardiovascular disease in a cohort of HIV-infected and HIV-negative subjects. This study includes longitudinal measurements of iohexol clearance (a gold-standard measure of glomerular filtration rate), surrogate measures of cardiovascular disease, and the opportunity to assess putative mechanisms and novel biomarkers through stored specimens. Second, Dr. Lucas is co-PI of a cluster-randomized trial to evaluate the effectiveness of IDU-friendly integrated care centers (ICCs) in India. After baseline data collection and stratification, 12 IDU-prevalent sites in India will be randomized to ICC or control. In the 6 ICC sites, IDU- oriented non-governmental organizations will be scaled-up to provide free HIV testing and on-site ART, in addition to counseling and risk reduction services. After 2 years of service delivery, community-level outcomes will be evaluated with respondent-driven sampling surveys of 1,000 IDUs in each experimental and control site. In addition to these research platforms, Dr. Lucas proposes plans to assist the entry of junior investigators into HIV clinical research through a major commitment to the Johns Hopkins Center for AIDS Research (CFAR) and through his role as kidney disease working group director in the North American AIDS Cohort Collaboration on Research and Design (NA ACCORD). The outstanding environment for HIV research at Johns Hopkins is a key backdrop to this proposal. Dr. Lucas's training, experience, and career goals are well- suited to the objectives of the K24 award.

Public Health Relevance

This is a proposal for a midcareer investigator award in patient-oriented research for Gregory Lucas, Associate Professor at the Johns Hopkins School of Medicine. Dr. Lucas conducts research addressing barriers to HIV treatment and medical comorbidity in populations of HIV-infected injection drug users. The objective of this proposal is to support a program for mentoring junior investigators and for fostering innovative epidemiologic and implementation research targeting underserved populations.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
1K24DA035684-01A1
Application #
8729169
Study Section
AIDS Clinical Studies and Epidemiology Study Section (ACE)
Program Officer
Kahana, Shoshana Y
Project Start
2014-04-01
Project End
2019-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Solomon, Sunil S; Lucas, Gregory M; Celentano, David D et al. (2016) Design of the Indian NCA study (Indian national collaboration on AIDS): a cluster randomized trial to evaluate the effectiveness of integrated care centers to improve HIV outcomes among men who have sex with men and persons who inject drugs in India. BMC Health Serv Res 16:652
McFall, Allison M; Mehta, Shruti H; Srikrishnan, Aylur K et al. (2016) Getting to 90: linkage to HIV care among men who have sex with men and people who inject drugs in India. AIDS Care 28:1230-9
Lucas, Gregory M; Atta, Mohamed G; Fine, Derek M et al. (2016) HIV, Cocaine Use, and Hepatitis C Virus: A Triad of Nontraditional Risk Factors for Subclinical Cardiovascular Disease. Arterioscler Thromb Vasc Biol 36:2100-7
Lucas, Gregory M; Atta, Mohamed G; Zook, Katie et al. (2016) Factors associated with iohexol-based glomerular filtration rate slope over 36 months in HIV-negative and HIV-positive individuals. AIDS 30:619-26
Solomon, Sunil Suhas; Mehta, Shruti H; McFall, Allison M et al. (2016) Community viral load, antiretroviral therapy coverage, and HIV incidence in India: a cross-sectional, comparative study. Lancet HIV 3:e183-90
Solomon, Sunil S; Mehta, Shruti H; Srikrishnan, Aylur K et al. (2015) High HIV prevalence and incidence among MSM across 12 cities in India. AIDS 29:723-31
Abraham, Alison G; Althoff, Keri N; Jing, Yuezhou et al. (2015) End-stage renal disease among HIV-infected adults in North America. Clin Infect Dis 60:941-9
Waheed, Sana; Attia, Doaa; Estrella, Michelle M et al. (2015) Proximal tubular dysfunction and kidney injury associated with tenofovir in HIV patients: a case series. Clin Kidney J 8:420-5
Achhra, A C; Mocroft, A; Ross, M J et al. (2015) Kidney disease in antiretroviral-naïve HIV-positive adults with high CD4 counts: prevalence and predictors of kidney disease at enrolment in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial. HIV Med 16 Suppl 1:55-63
Kitahata, Mari M; Drozd, Daniel R; Crane, Heidi M et al. (2015) Ascertainment and verification of end-stage renal disease and end-stage liver disease in the north american AIDS cohort collaboration on research and design. AIDS Res Treat 2015:923194

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