This renewal application for a Mid-career Investigator Award (K24) in Patient Oriented Research (POR) seeks support for an investigator who is committed to excellent research in human nutrition, and to mentoring future leaders in Pediatric Nutrition. The objective of the application is to enable the candidate to continue her efforts in POR, and to foster her ability to mentor clinical investigators and other trainees in Pediatric Nutrition. The candidate has an excellent record of conducting POR, which has been funded by both federal and non-federal sources. During the first four years of her original K24 award, she has coauthored 47 publications and 30 abstracts, and she has mentored 20 pre- and post-doctoral trainees, including 4 physician fellows, and 3 post-doctoral fellows, all of whom conducted research projects directly relevant to Pediatric Nutrition. The candidate's primary research focus is micronutrient nutrition, especially in infants and young children. She is currently conducting several trials related to zinc (Zn) homeostasis and bioavailability in developing countries. A second area of interest and collaborative research is pediatric obesity prevention and treatment. Three funded POR projects are described in the application: a cluster randomized trial providing meat as a complementary food to infants and toddlers in 4 developing countries;a metabolic study comparing 3 different complementary feeding regimens in U.S. breastfed infants;and a pilot study examining the feasibility of an office-based electronic system to enhance providers'assessment of obesity and cardiovascular disease risk in children. The specific mentoring aims are 1) to recruit outstanding trainees, especially physicians, to the field of Pediatric Nutrition so as to increase the number of physician leaders in this area;and 2) to implement a structured, rigorous training program for post-doctoral fellows in Pediatric Nutrition through an updated, collaborative training track. This award will substantially contribute to the candidate's career goals by enabling her to relinquish some clinical and administrative duties and to take advantage of career enhancement opportunities, both of which will enhance her ability to mentor the next generation of clinical investigators. Relevance: This project addresses human nutrition research in two major areas of public health importance in Pediatrics: micronutrient deficiencies and obesity. The award seeks support for an applicant who has a long track record of conducting patient oriented research and of mentoring clinical investigators in the area of Pediatric Nutrition.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK083772-09
Application #
8249498
Study Section
Special Emphasis Panel (ZDK1-GRB-7 (J2))
Program Officer
Podskalny, Judith M,
Project Start
2003-04-01
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
9
Fiscal Year
2012
Total Cost
$160,982
Indirect Cost
$11,925
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Tang, Minghua; Frank, Daniel N; Sherlock, Laurie et al. (2016) Effect of Vitamin E With Therapeutic Iron Supplementation on Iron Repletion and Gut Microbiome in US Iron Deficient Infants and Toddlers. J Pediatr Gastroenterol Nutr 63:379-85
Rudolph, Michael C; Young, Bridget E; Jackson, Kristina Harris et al. (2016) Human Milk Fatty Acid Composition: Comparison of Novel Dried Milk Spot Versus Standard Liquid Extraction Methods. J Mammary Gland Biol Neoplasia 21:131-138
May, Thaddaeus; Westcott, Claire; Thakwalakwa, Chrissie et al. (2015) Resistant starch does not affect zinc homeostasis in rural Malawian children. J Trace Elem Med Biol 30:43-8
Miller, Leland V; Hambidge, K Michael; Krebs, Nancy F (2015) Zinc Absorption Is Not Related to Dietary Phytate Intake in Infants and Young Children Based on Modeling Combined Data from Multiple Studies. J Nutr 145:1763-9
Tang, Minghua; Krebs, Nancy F (2014) High protein intake from meat as complementary food increases growth but not adiposity in breastfed infants: a randomized trial. Am J Clin Nutr 100:1322-8
Krebs, Nancy F (2014) Food Based Complementary Feeding Strategies for Breastfed Infants: What's the Evidence that it Matters? Nutr Today 49:271-277
Esamai, Fabian; Liechty, Edward; Ikemeri, Justus et al. (2014) Zinc absorption from micronutrient powder is low but is not affected by iron in Kenyan infants. Nutrients 6:5636-51
Gaensbauer, James T; Rakhola, Jeremy T; Onyango-Makumbi, Carolyne et al. (2014) Impaired haemophilus influenzae type b transplacental antibody transmission and declining antibody avidity through the first year of life represent potential vulnerabilities for HIV-exposed but -uninfected infants. Clin Vaccine Immunol 21:1661-7
Newman, Jamie E; Garces, Ana; Mazariegos, Manolo et al. (2014) Theory-driven process evaluation of a complementary feeding trial in four countries. Health Educ Res 29:297-305
Tang, Minghua; Sheng, Xiao-Yang; Krebs, Nancy F et al. (2014) Meat as complementary food for older breastfed infants and toddlers: a randomized, controlled trial in rural China. Food Nutr Bull 35:S188-92

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