This renewal application for a Mid-career Investigator Award (K24) in Patient Oriented Research (POR) seeks support for an investigator who is committed to excellent research in human nutrition, and to mentoring future leaders in Pediatric Nutrition. The objective of the application is to enable the candidate to continue her efforts in POR, and to foster her ability to mentor clinical investigators and other trainees in Pediatric Nutrition. The candidate has an excellent record of conducting POR, which has been funded by both federal and non-federal sources. During the first four years of her original K24 award, she has coauthored 47 publications and 30 abstracts, and she has mentored 20 pre- and post-doctoral trainees, including 4 physician fellows, and 3 post-doctoral fellows, all of whom conducted research projects directly relevant to Pediatric Nutrition. The candidate's primary research focus is micronutrient nutrition, especially in infants and young children. She is currently conducting several trials related to zinc (Zn) homeostasis and bioavailability in developing countries. A second area of interest and collaborative research is pediatric obesity prevention and treatment. Three funded POR projects are described in the application: a cluster randomized trial providing meat as a complementary food to infants and toddlers in 4 developing countries;a metabolic study comparing 3 different complementary feeding regimens in U.S. breastfed infants;and a pilot study examining the feasibility of an office-based electronic system to enhance providers'assessment of obesity and cardiovascular disease risk in children. The specific mentoring aims are 1) to recruit outstanding trainees, especially physicians, to the field of Pediatric Nutrition so as to increase the number of physician leaders in this area;and 2) to implement a structured, rigorous training program for post-doctoral fellows in Pediatric Nutrition through an updated, collaborative training track. This award will substantially contribute to the candidate's career goals by enabling her to relinquish some clinical and administrative duties and to take advantage of career enhancement opportunities, both of which will enhance her ability to mentor the next generation of clinical investigators. Relevance: This project addresses human nutrition research in two major areas of public health importance in Pediatrics: micronutrient deficiencies and obesity. The award seeks support for an applicant who has a long track record of conducting patient oriented research and of mentoring clinical investigators in the area of Pediatric Nutrition.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Special Emphasis Panel (ZDK1-GRB-7 (J2))
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Podskalny, Judith M,
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University of Colorado Denver
Schools of Medicine
United States
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Young, B E; Levek, C; Reynolds, R M et al. (2018) Bioactive components in human milk are differentially associated with rates of lean and fat mass deposition in infants of mothers with normal vs. elevated BMI. Pediatr Obes 13:598-606
Rudolph, M C; Young, B E; Lemas, D J et al. (2017) Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes (Lond) 41:510-517
Young, B E; Patinkin, Z; Palmer, C et al. (2017) Human milk insulin is related to maternal plasma insulin and BMI: but other components of human milk do not differ by BMI. Eur J Clin Nutr 71:1094-1100
Young, Bridget E; Patinkin, Zachary W; Pyle, Laura et al. (2017) Markers of Oxidative Stress in Human Milk do not Differ by Maternal BMI But are Related to Infant Growth Trajectories. Matern Child Health J 21:1367-1376
Ariff, Shabina; Krebs, Nancy F; Westcott, Jamie E et al. (2017) Exchangeable Zinc Pool Size at Birth in Pakistani SGA and AGA Infants Do Not Differ but are Lower than in US Infants. J Pediatr Gastroenterol Nutr :
Young, B E; Farazandeh, S; Westra, K et al. (2016) Maternal Beliefs Surrounding Infant Feeding, but Not Maternal BMI or Hospital Experience, Predict Breastfeeding Exclusivity and Behavior. Austin J Pediatr 3:
Tang, Minghua; Frank, Daniel N; Sherlock, Laurie et al. (2016) Effect of Vitamin E With Therapeutic Iron Supplementation on Iron Repletion and Gut Microbiome in US Iron Deficient Infants and Toddlers. J Pediatr Gastroenterol Nutr 63:379-85
Rudolph, Michael C; Young, Bridget E; Jackson, Kristina Harris et al. (2016) Human Milk Fatty Acid Composition: Comparison of Novel Dried Milk Spot Versus Standard Liquid Extraction Methods. J Mammary Gland Biol Neoplasia 21:131-138
Miller, Leland V; Hambidge, K Michael; Krebs, Nancy F (2015) Zinc Absorption Is Not Related to Dietary Phytate Intake in Infants and Young Children Based on Modeling Combined Data from Multiple Studies. J Nutr 145:1763-9
May, Thaddaeus; Westcott, Claire; Thakwalakwa, Chrissie et al. (2015) Resistant starch does not affect zinc homeostasis in rural Malawian children. J Trace Elem Med Biol 30:43-48

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