Dr. Murphy is a well-established, well-funded and productive researcher who has productively utilized the K24 mechanism during the first funding period to leverage his participation in patient oriented research (POR) and to devote substantial additional time to training and mentoring. He has been successful in traditional mentoring of graduate students, fellows and junior faculty towards their own career in POR. More novel, but still fully within the scope of the K24 award's intent, he has instituted a dynamic new program in POR training for transfusion medicine MD's and PhD's in developing countries that will lead to a new generation of researchers devoted to improving the safety and availability of blood transfusion on a worldwide basis. Finally, there are still competing demands for time and funded salary between research and training activities and remaining commitments to administrative duties. Although medium-long term mentorship has been successful, the international program is still young and the applicant would like more time for several promising trainees from the short course to transition to medium to long term mentorship. An additional five years of funding is requested to enable the formation of a Center of Excellence in POR training in international transfusion safety: ? Continue and expand his program of high quality POR, with a research concentration on the health outcomes of transfusion transmitted viruses and genetic epidemiology. ? Continue and increase medium- and long-term mentorship under the umbrella of the UCSF CTSI, UC Berkeley School of Public Health and the new roadmap K12 Masters and Ph.D. programs at UCSF. ? Expand and obtain independent funding for international training activities, in collaboration with the UCSF Institute for Global Health, and NIH Fogarty International Center training grants ? Further strengthen his own research team, promoting the independence of junior faculty and a joint (UCSF and BSRI) recruitment of a genetic epidemiologist to aid the laboratory's expansion into this new area of research.

Public Health Relevance

This research training grant will support the applicant in his efforts to perform patient oriented research, and to train younger physician scientists to do this kind of research. The proposal will train graduate students, postdoctoral fellows and junior faculty in the USA and transfusion doctors in developing countries.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24HL075036-10
Application #
8474822
Study Section
Special Emphasis Panel (ZHL1-CSR-R (M1))
Program Officer
Welniak, Lisbeth A
Project Start
2004-01-05
Project End
2014-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
10
Fiscal Year
2013
Total Cost
$178,626
Indirect Cost
$12,159
Name
University of California San Francisco
Department
Pathology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Chang, Yun Brenda; Kaidarova, Zhanna; Hindes, Daniel et al. (2014) Seroprevalence and demographic determinants of human T-lymphotropic virus type 1 and 2 infections among first-time blood donors--United States, 2000-2009. J Infect Dis 209:523-31
Roubinian, Nareg H; Murphy, Edward L; Swain, Bix E et al. (2014) Predicting red blood cell transfusion in hospitalized patients: role of hemoglobin level, comorbidities, and illness severity. BMC Health Serv Res 14:213
Bloch, E M; Shah, A; Kaidarova, Z et al. (2014) A pilot external quality assurance study of transfusion screening for HIV, HCV and HBsAG in 12 African countries. Vox Sang 107:333-42
Murphy, Edward L (2013) Health outcomes in recipients of blood transfusion - observational studies versus randomized clinical trials. ISBT Sci Ser 8:172-176
Murphy, Edward L; Kwaan, Nicholas; Looney, Mark R et al. (2013) Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med 126:357.e29-38
Guiltinan, Anne M; Kaidarova, Zhanna; Behan, Dee et al. (2013) Major depression and generalized anxiety disorder among human T-lymphotropic virus types I- and II-infected former blood donors. Transfusion 53:60-8
de Almeida-Neto, Cesar; Sabino, Ester Cerdeira; Liu, Jing et al. (2013) Prevalence of serologic markers for hepatitis B and C viruses in Brazilian blood donors and incidence and residual risk of transfusion transmission of hepatitis C virus. Transfusion 53:827-34
Sabino, Ester C; Ribeiro, Antonio L; Salemi, Vera M C et al. (2013) Ten-year incidence of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi-seropositive former blood donors. Circulation 127:1105-15
Douceron, Estelle; Kaidarova, Zhanna; Miyazato, Paola et al. (2012) HTLV-2 APH-2 expression is correlated with proviral load but APH-2 does not promote lymphocytosis. J Infect Dis 205:82-6
Nebie, Koumpingnin; Ouattara, Siaka; Sanou, Mahamoudou et al. (2011) Poor procedures and quality control among nonaffiliated blood centers in Burkina Faso: an argument for expanding the reach of the national blood transfusion center. Transfusion 51:1613-8

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