Abstract

At the mid-point of my academic career, I have been productive in patient-oriented research, as documented by publications in a number of prominent journals, evidence of national and international recognition, and a good funding record from the NIH and other funding sources. My Epidemiology Research Laboratory does clinical epidemiology research in the health outcomes of human retroviruses human T-lymphotropic virus types I and II (HTLV-I and -II), and my NIH R01-funded multicenter HTLV cohort study forms the centerpiece of the Research Plan in this application. I also study the epidemiology of transfusion-transmitted viruses and of blood donor demographics and donation behavior. My current research environment includes both the UCSF Departments of Laboratory Medicine and Epidemiology & Biostatistics, my academic home, and Blood Centers of the Pacific (BCP), a community blood bank 1 mile from the UCSF campus where my Epidemiology Lab and close collaborators are located. Letters from the heads of these institutions support my K24 application, and document the strong affiliations in research and training between UCSF and BCP. I have already mentored a number of graduate students and postdoctoral researchers, as well as several professionals seeking additional training in clinical epidemiology research. I am applying for a K24 grant at this point because I would like to reduce my effort on clinical duties and specific funded projects in order to pursue new interests in patient-oriented research and to expand my mentoring activities. The new trainees would carry out supervised epidemiology research projects in HTLV clinical outcomes, in transfusion transmitted viral infections, or a new area in the epidemiology of blood donor demographics and donation behavior. They will participate in the Training in Clinical Research courses given by the UCSF Department of Epidemiology and Biostatistics. Finally, I shall expand an existing training program in International Transfusion Safety organized by BCP under an NIH Fogarty International Center grant. This program brings blood bankers from less developed countries for an intensive summer training program in research methods related to blood safety.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24HL075036-03
Application #
6991203
Study Section
Special Emphasis Panel (ZHL1-CSR-J (O1))
Program Officer
Werner, Ellen
Project Start
2004-01-05
Project End
2008-12-31
Budget Start
2006-01-01
Budget End
2006-12-31
Support Year
3
Fiscal Year
2006
Total Cost
$132,257
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Pathology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Porto-Ferreira, Francisco Augusto; de Almeida-Neto, Cesar; Murphy, Edward L et al. (2017) A randomized trial to evaluate the use of text messaging, letter, and telephone call reminders to improve return of blood donors with reactive serologic tests. Transfusion 57:102-107
Betsem, Edouard; Kaidarova, Zhanna; Stramer, Susan L et al. (2017) Correlation of West Nile Virus Incidence in Donated Blood with West Nile Neuroinvasive Disease Rates, United States, 2010-2012. Emerg Infect Dis 23:212-219
Prugger, C; Laperche, S; Murphy, E L et al. (2016) Screening for transfusion transmissible infections using rapid diagnostic tests in Africa: a potential hazard to blood safety? Vox Sang 110:196-8
Usadi, Benjamin; Bruhn, Roberta; Lin, Jue et al. (2016) Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects. Viruses 8:
Tagny, C T; Ndoumba, A; Laperche, S et al. (2016) Reducing risks of Transfusion-transmitted infections in a resource-limited hospital-based blood bank: the case of the Yaoundé University Teaching Hospital, Cameroon. ISBT Sci Ser 11:82-87
Murphy, E L (2016) Infection with human T-lymphotropic virus types-1 and -2 (HTLV-1 and -2): Implications for blood transfusion safety. Transfus Clin Biol 23:13-9
Vo, Michelle T; Bruhn, Roberta; Kaidarova, Zhanna et al. (2016) A retrospective analysis of false-positive infectious screening results in blood donors. Transfusion 56:457-65
Roubinian, Nareg H; Looney, Mark R; Kor, Daryl J et al. (2015) Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion 55:1838-46
Kane, Mark Andrew; Bloch, Evan Martin; Bruhn, Roberta et al. (2015) Demographic determinants of syphilis seroprevalence among U.S. blood donors, 2011-2012. BMC Infect Dis 15:63
Carneiro-Proietti, A B F; Amaranto-Damasio, M S; Leal-Horiguchi, C F et al. (2014) Mother-to-Child Transmission of Human T-Cell Lymphotropic Viruses-1/2: What We Know, and What Are the Gaps in Understanding and Preventing This Route of Infection. J Pediatric Infect Dis Soc 3 Suppl 1:S24-9

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