This application is a competitive renewal for a Mid-Career Development Award (K24-MH074457) designed to promote the continued development of the applicant (James Lock, MD, Ph.D) in conducting novel research and mentoring students and other investigators in the area of child and adolescent eating disorders. The applicant is active in developing and testing new treatments for eating disorders, mentoring new investigators, and developing his capacities to conduct neurocognitive and neurofunctional research as outlined in his previous award. This expansion of the scale and focus of Dr. Lock's research and mentoring activities was the direct result of having had the Mid-Career Development Award. In order to make continued progress in patient oriented research in the area of child and adolescent eating disorders and to continue to mentor young investigators, support for an additional 5 years is proposed in this application. Dr. Lock's own development as a research scientist would benefit from an additional period of Mid-Career Development by obtaining further training in neuroimaging research and in genetic research methods to be applied to eating disorder populations and by providing resources for additional mentoring for future scientists in the area of eating disorder research. This application has the following specific aims: 1) To continue to develop and test novel treatments for child and adolescent eating disorders, including enhancing a research network for anorexia nervosa research and dissemination;2) To promote translational research in the neurosciences in patient oriented research related to eating disorders through advanced training in imaging research and new training in psychiatric genetic research;3) To increase the number of trained researchers capable of conducting clinical research and translational research in child and adolescent eating disorders through mentoring and research training. The range of currently funded research and planned research provides an essential scaffold for research training.
This application is a proposal to continue to provide the applicant with support to mentor investigators and develop scientists in patient oriented research in eating disorders. The applicant's current research activities and his base in the Department of Psychiatry at Stanford University provide the platform for providing this type of scientific mentoring. In addition, this application proposes to support the development of the applicant's translational neuroscience training through advanced training in neuroimaging and initiating training in psychiatric genetics. Didactic, consultative, and experiential learning activities are proposed. A pilot project is proposed to investigate family aggregation of cognitive inefficiencies in eating disorders.
|Le Grange, Daniel; Lock, James; Accurso, Erin C et al. (2014) Relapse from remission at two- to four-year follow-up in two treatments for adolescent anorexia nervosa. J Am Acad Child Adolesc Psychiatry 53:1162-7|
|Garrett, Amy S; Lock, James; Datta, Nandini et al. (2014) Predicting clinical outcome using brain activation associated with set-shifting and central coherence skills in Anorexia Nervosa. J Psychiatr Res 57:26-33|
|Forsberg, Sarah; LoTempio, Elizabeth; Bryson, Susan et al. (2013) Therapeutic alliance in two treatments for adolescent anorexia nervosa. Int J Eat Disord 46:34-8|
|Darcy, Alison M; Doyle, Angela Celio; Lock, James et al. (2012) The Eating Disorders Examination in adolescent males with anorexia nervosa: how does it compare to adolescent females? Int J Eat Disord 45:110-4|
|Lock, James; Brandt, Harry; Woodside, Blake et al. (2012) Challenges in conducting a multi-site randomized clinical trial comparing treatments for adolescent anorexia nervosa. Int J Eat Disord 45:202-13|
|Le Grange, Daniel; Lock, James; Agras, W Stewart et al. (2012) Moderators and mediators of remission in family-based treatment and adolescent focused therapy for anorexia nervosa. Behav Res Ther 50:85-92|
|Hoste, Renee Rienecke; Labuschagne, Zandre; Lock, James et al. (2012) Cultural variability in Expressed Emotion among families of adolescents with anorexia nervosa. Int J Eat Disord 45:142-5|
|Peebles, Rebecka; Wilson, Jenny L; Lock, James D (2011) Self-injury in adolescents with eating disorders: correlates and provider bias. J Adolesc Health 48:310-3|
|Le Grange, Daniel; Hoste, Renee Rienecke; Lock, James et al. (2011) Parental expressed emotion of adolescents with anorexia nervosa: outcome in family-based treatment. Int J Eat Disord 44:731-4|
|Lock, James; Garrett, Amy; Beenhakker, Judy et al. (2011) Aberrant brain activation during a response inhibition task in adolescent eating disorder subtypes. Am J Psychiatry 168:55-64|
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