This application is a competitive renewal for a Mid-Career Development Award (K24-MH074457) designed to promote the continued development of the applicant (James Lock, MD, Ph.D) in conducting novel research and mentoring students and other investigators in the area of child and adolescent eating disorders. The applicant is active in developing and testing new treatments for eating disorders, mentoring new investigators, and developing his capacities to conduct neurocognitive and neurofunctional research as outlined in his previous award. This expansion of the scale and focus of Dr. Lock's research and mentoring activities was the direct result of having had the Mid-Career Development Award. In order to make continued progress in patient oriented research in the area of child and adolescent eating disorders and to continue to mentor young investigators, support for an additional 5 years is proposed in this application. Dr. Lock's own development as a research scientist would benefit from an additional period of Mid-Career Development by obtaining further training in neuroimaging research and in genetic research methods to be applied to eating disorder populations and by providing resources for additional mentoring for future scientists in the area of eating disorder research. This application has the following specific aims: 1) To continue to develop and test novel treatments for child and adolescent eating disorders, including enhancing a research network for anorexia nervosa research and dissemination;2) To promote translational research in the neurosciences in patient oriented research related to eating disorders through advanced training in imaging research and new training in psychiatric genetic research;3) To increase the number of trained researchers capable of conducting clinical research and translational research in child and adolescent eating disorders through mentoring and research training. The range of currently funded research and planned research provides an essential scaffold for research training.

Public Health Relevance

This application is a proposal to continue to provide the applicant with support to mentor investigators and develop scientists in patient oriented research in eating disorders. The applicant's current research activities and his base in the Department of Psychiatry at Stanford University provide the platform for providing this type of scientific mentoring. In addition, this application proposes to support the development of the applicant's translational neuroscience training through advanced training in neuroimaging and initiating training in psychiatric genetics. Didactic, consultative, and experiential learning activities are proposed. A pilot project is proposed to investigate family aggregation of cognitive inefficiencies in eating disorders.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Special Emphasis Panel (ZMH1)
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Avenevoli, Shelli A
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Stanford University
Schools of Medicine
United States
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Rienecke, Renee D; Accurso, Erin C; Lock, James et al. (2016) Expressed Emotion, Family Functioning, and Treatment Outcome for Adolescents with Anorexia Nervosa. Eur Eat Disord Rev 24:43-51
Rienecke, Renee D; Sim, Leslie; Lock, James et al. (2016) Patterns of expressed emotion in adolescent eating disorders. J Child Psychol Psychiatry 57:1407-1413
Le Grange, Daniel (2016) Anorexia nervosa in adults: The urgent need for novel outpatient treatments that work. Psychotherapy (Chic) 53:251-4
Le Grange, Daniel; Lock, James; Agras, W Stewart et al. (2015) Randomized Clinical Trial of Family-Based Treatment and Cognitive-Behavioral Therapy for Adolescent Bulimia Nervosa. J Am Acad Child Adolesc Psychiatry 54:886-94.e2
Forsberg, Sarah; Fitzpatrick, Kathleen Kara; Darcy, Alison et al. (2015) Development and evaluation of a treatment fidelity instrument for family-based treatment of adolescent anorexia nervosa. Int J Eat Disord 48:91-9
Lock, James; Le Grange, Daniel; Agras, W Stewart et al. (2015) Can adaptive treatment improve outcomes in family-based therapy for adolescents with anorexia nervosa? Feasibility and treatment effects of a multi-site treatment study. Behav Res Ther 73:90-5
Byrne, Catherine E; Accurso, Erin C; Arnow, Katherine D et al. (2015) An exploratory examination of patient and parental self-efficacy as predictors of weight gain in adolescents with anorexia nervosa. Int J Eat Disord 48:883-8
Ciao, Anna C; Accurso, Erin C; Fitzsimmons-Craft, Ellen E et al. (2015) Family functioning in two treatments for adolescent anorexia nervosa. Int J Eat Disord 48:81-90
Le Grange, Daniel; Accurso, Erin C; Lock, James et al. (2014) Early weight gain predicts outcome in two treatments for adolescent anorexia nervosa. Int J Eat Disord 47:124-9
Le Grange, Daniel; Lock, James; Accurso, Erin C et al. (2014) Relapse from remission at two- to four-year follow-up in two treatments for adolescent anorexia nervosa. J Am Acad Child Adolesc Psychiatry 53:1162-7

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