The proposed midcareer investigator Award in Patient-Oriented Research (K24) will support the career development of Helen Blair Simpson, MD PhD, a clinical researcher who is dedicated to improving the lives of people with obsessive-compulsive disorder (OCD). The Career Development Plan will enhance the candidate's ability 1) to conduct patient-oriented research by receiving training in three specific areas: functional magnetic resonance imaging, advanced statistical methods, and novel clinical trial designs;and 2) to mentor patient-oriented researchers by receiving training in scientific leadership and cultural competence. The Mentoring Plan describes training for research fellows, K-awardees, and junior faculty in patient-oriented research. Under supervision by the candidate, mentees will obtain hand-on experience in methods for conducting patient-oriented research and will develop their own independent research directions. The Research Plan includes funded projects that focus on clinical trials but that also include neuroimaging and translational studies that Dr. Simpson conducts in collaboration with imaging experts and basic scientists, making for a rich training environment. It also includes a New Research Project with two aims: 1) to identify neurocognitive, neurophysiological, and neuroimaging biomarkers for OCD;and 2) to explore whether the pattern of performance across these measures generates a new way to classify OCD. Capitalizing on existing resources so as to be accomplished within the limits of the K24 research budget, this project will 1) enhance Dr. Simpson's research program and advance her capacity to conduct patient-oriented research;and 2) provide excellent opportunities for mentoring clinician-investigators.

Public Health Relevance

This is a grant application for a Midcareer Investigator Award in Patient-Oriented Research (K24) to enable Dr. Helen Blair Simpson to advance her capacity to conduct patient-oriented research and to enhance her ability to mentor clinician-investigators who seek to conduct patient-oriented research. The application is based on the candidate's interdisciplinary program focused on obsessive-compulsive disorder (OCD). It proposes a focused training program for the candidate, a plan for mentoring clinician-investigators in patient-oriented research, and a pilot project to identify biomarkers/behavioral indicators for OCD, an objective of the NIMH strategic plan.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24MH091555-03
Application #
8257574
Study Section
Special Emphasis Panel (ZMH1-ERB-F (08))
Program Officer
Meinecke, Douglas L
Project Start
2010-09-01
Project End
2015-02-28
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
3
Fiscal Year
2012
Total Cost
$147,969
Indirect Cost
$9,503
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
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Patel, Sapana R; Humensky, Jennifer L; Olfson, Mark et al. (2014) Treatment of obsessive-compulsive disorder in a nationwide survey of office-based physician practice. Psychiatr Serv 65:681-4
Steinglass, Joanna E; Albano, Anne Marie; Simpson, H Blair et al. (2014) Confronting fear using exposure and response prevention for anorexia nervosa: A randomized controlled pilot study. Int J Eat Disord 47:174-80
Williams, Monnica T; Farris, Samantha G; Turkheimer, Eric N et al. (2014) The impact of symptom dimensions on outcome for exposure and ritual prevention therapy in obsessive-compulsive disorder. J Anxiety Disord 28:553-8
Ahmari, Susanne E; Eich, Teal; Cebenoyan, Deniz et al. (2014) Assessing neurocognitive function in psychiatric disorders: a roadmap for enhancing consensus. Neurobiol Learn Mem 115:10-20
Simpson, H Blair; Wetterneck, Chad T; Cahill, Shawn P et al. (2013) Treatment of obsessive-compulsive disorder complicated by comorbid eating disorders. Cogn Behav Ther 42:64-76
Ahmari, Susanne E; Risbrough, Victoria B; Geyer, Mark A et al. (2012) Impaired sensorimotor gating in unmedicated adults with obsessive-compulsive disorder. Neuropsychopharmacology 37:1216-23
Pinto, Anthony; Liebowitz, Michael R; Foa, Edna B et al. (2011) Obsessive compulsive personality disorder as a predictor of exposure and ritual prevention outcome for obsessive compulsive disorder. Behav Res Ther 49:453-8