HIV+ patients are aging, due in large part to the successes of combination antiretroviral medications. Despite these accomplishments, over 50% of community dwelling HIV+ patients have cognitive impairment, a frequency that increases with age. The candidate of this application has developed a robust clinical research environment to address brain vulnerability in the setting of HIV. His training in internal medicine, geriatric medicine and neurobehavior allow him to link disciplines and inform the cognitive consequences of aging with HIV. The work proposed in this application will enhance and stabilize his career development to focus more directly on training the next generation of high quality patient-oriented researchers. The proposed science will focus on the functional consequence of cognitive impairment in HIV over age 60 and the co-existence of geriatric syndromes. Unique features of the mentoring plan include access to networks of patients, a passion for training early-stage investigators, and the multi-disciplinary training of the candidate.

Public Health Relevance

The work proposed in this application will train the next generation of clinician researchers in geriatric and cognitive science as it relates to HIV. This s critically important as the population of HIV+ patients in the US ages so that optimal health outcomes can be achieved.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
1K24MH098759-01A1
Application #
8467495
Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Stoff, David M
Project Start
2012-12-06
Project End
2017-11-30
Budget Start
2012-12-06
Budget End
2013-11-30
Support Year
1
Fiscal Year
2013
Total Cost
$179,178
Indirect Cost
$13,272
Name
University of California San Francisco
Department
Neurology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Hellmuth, Joanna; Milanini, Benedetta; Valcour, Victor (2014) Interactions between ageing and NeuroAIDS. Curr Opin HIV AIDS 9:527-32
Milanini, Benedetta; Wendelken, Lauren A; Esmaeili-Firidouni, Pardis et al. (2014) The Montreal cognitive assessment to screen for cognitive impairment in HIV patients older than 60 years. J Acquir Immune Defic Syndr 67:67-70
Greene, Meredith; Justice, Amy C; Lampiris, Harry W et al. (2013) Management of human immunodeficiency virus infection in advanced age. JAMA 309:1397-405