HIV+ patients are aging, due in large part to the successes of combination antiretroviral medications. Despite these accomplishments, over 50% of community dwelling HIV+ patients have cognitive impairment, a frequency that increases with age. The candidate of this application has developed a robust clinical research environment to address brain vulnerability in the setting of HIV. His training in internal medicine, geriatric medicine and neurobehavior allow him to link disciplines and inform the cognitive consequences of aging with HIV. The work proposed in this application will enhance and stabilize his career development to focus more directly on training the next generation of high quality patient-oriented researchers. The proposed science will focus on the functional consequence of cognitive impairment in HIV over age 60 and the co-existence of geriatric syndromes. Unique features of the mentoring plan include access to networks of patients, a passion for training early-stage investigators, and the multi-disciplinary training of the candidate.

Public Health Relevance

The work proposed in this application will train the next generation of clinician researchers in geriatric and cognitive science as it relates to HIV. This s critically important as the population of HIV+ patients in the US ages so that optimal health outcomes can be achieved.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Stoff, David M
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University of California San Francisco
Schools of Medicine
San Francisco
United States
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Hellmuth, Joanna; Fletcher, James L K; Valcour, Victor et al. (2016) Neurologic signs and symptoms frequently manifest in acute HIV infection. Neurology 87:148-54
Valcour, Victor G; Rubin, Leah H; Obasi, Mary U et al. (2016) Liver Fibrosis Linked to Cognitive Performance in HIV and Hepatitis C. J Acquir Immune Defic Syndr 72:266-73
Guha, Anika; Wang, Liang; Tanenbaum, Aaron et al. (2016) Intrinsic network connectivity abnormalities in HIV-infected individuals over age 60. J Neurovirol 22:80-7
Zhang, Yong; Kwon, Dongjin; Esmaeili-Firidouni, Pardis et al. (2016) Extracting patterns of morphometry distinguishing HIV associated neurodegeneration from mild cognitive impairment via group cardinality constrained classification. Hum Brain Mapp :
Wendelken, Lauren A; Jahanshad, Neda; Rosen, Howard J et al. (2016) ApoE ε4 Is Associated With Cognition, Brain Integrity, and Atrophy in HIV Over Age 60. J Acquir Immune Defic Syndr 73:426-432
Chan, Phillip; Hellmuth, Joanna; Spudich, Serena et al. (2016) Cognitive Impairment and Persistent CNS Injury in Treated HIV. Curr HIV/AIDS Rep 13:209-17
Maki, Pauline M; Rubin, Leah H; Valcour, Victor et al. (2015) Cognitive function in women with HIV: findings from the Women's Interagency HIV Study. Neurology 84:231-40
Wade, Benjamin S C; Valcour, Victor G; Wendelken-Riegelhaupt, Lauren et al. (2015) Mapping abnormal subcortical brain morphometry in an elderly HIV+ cohort. Neuroimage Clin 9:564-73
Milanini, Benedetta; Wendelken, Lauren A; Esmaeili-Firidouni, Pardis et al. (2014) The Montreal cognitive assessment to screen for cognitive impairment in HIV patients older than 60 years. J Acquir Immune Defic Syndr 67:67-70
Greene, Meredith; Steinman, Michael A; McNicholl, Ian R et al. (2014) Polypharmacy, drug-drug interactions, and potentially inappropriate medications in older adults with human immunodeficiency virus infection. J Am Geriatr Soc 62:447-53

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