HIV+ patients are aging, due in large part to the successes of combination antiretroviral medications. Despite these accomplishments, over 50% of community dwelling HIV+ patients have cognitive impairment, a frequency that increases with age. The candidate of this application has developed a robust clinical research environment to address brain vulnerability in the setting of HIV. His training in internal medicine, geriatric medicine and neurobehavior allow him to link disciplines and inform the cognitive consequences of aging with HIV. The work proposed in this application will enhance and stabilize his career development to focus more directly on training the next generation of high quality patient-oriented researchers. The proposed science will focus on the functional consequence of cognitive impairment in HIV over age 60 and the co-existence of geriatric syndromes. Unique features of the mentoring plan include access to networks of patients, a passion for training early-stage investigators, and the multi-disciplinary training of the candidate.

Public Health Relevance

The work proposed in this application will train the next generation of clinician researchers in geriatric and cognitive science as it relates to HIV. This s critically important as the population of HIV+ patients in the US ages so that optimal health outcomes can be achieved.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24MH098759-02
Application #
8593316
Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Stoff, David M
Project Start
2012-12-06
Project End
2017-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
2
Fiscal Year
2014
Total Cost
$178,528
Indirect Cost
$13,224
Name
University of California San Francisco
Department
Neurology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Samboju, Vishal; Philippi, Carissa L; Chan, Phillip et al. (2018) Structural and functional brain imaging in acute HIV. Neuroimage Clin 20:327-335
Narvid, J; McCoy, D; Dupont, S M et al. (2018) Abnormal Cerebral Perfusion Profile in Older Adults with HIV-Associated Neurocognitive Disorder: Discriminative Power of Arterial Spin-Labeling. AJNR Am J Neuroradiol 39:2211-2217
Adeli, Ehsan; Kwon, Dongjin; Zhao, Qingyu et al. (2018) Chained regularization for identifying brain patterns specific to HIV infection. Neuroimage 183:425-437
Huck, Daniel M; Hanna, David B; Rubin, Leah H et al. (2018) Carotid Artery Stiffness and Cognitive Decline Among Women With or at Risk for HIV Infection. J Acquir Immune Defic Syndr 78:338-347
Milanini, Benedetta; Paul, Robert; Bahemana, Emmanuel et al. (2018) Limitations of the International HIV Dementia Scale in the current era. AIDS 32:2477-2483
Premeaux, Thomas A; D'Antoni, Michelle L; Abdel-Mohsen, Mohamed et al. (2018) Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals. J Neurovirol :
Rubin, Leah H; Benning, Lorie; Keating, Sheila M et al. (2018) Variability in C-reactive protein is associated with cognitive impairment in women living with and without HIV: a longitudinal study. J Neurovirol 24:41-51
Rubin, Leah H; Cook, Judith A; Springer, Gayle et al. (2017) Perceived and post-traumatic stress are associated with decreased learning, memory, and fluency in HIV-infected women. AIDS 31:2393-1401
Kessing, Cari F; Spudich, Serena; Valcour, Victor et al. (2017) High Number of Activated CD8+ T Cells Targeting HIV Antigens Are Present in Cerebrospinal Fluid in Acute HIV Infection. J Acquir Immune Defic Syndr 75:108-117
Clifford, Katherine M; Samboju, Vishal; Cobigo, Yann et al. (2017) Progressive Brain Atrophy Despite Persistent Viral Suppression in HIV Patients Older Than 60 Years. J Acquir Immune Defic Syndr 76:289-297

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