Applying for our second CTSA, Tufts Clinical and Translational Science Institute (CTSl) remains avidly committed to involving the full spectrum of clinical ahd translational research (CTR) to meet th(c) promise of biomedical science, not only bench to bedside (T1"""""""") translation, crucial to having health impact, translation into effective clinical practice (""""""""T2""""""""), care delivery and public health (""""""""T3""""""""), and health policy ('T4""""""""). In 2008 we started Tufts CTSI building on prior CTR resources, services, and educational programs, we purposely selected partners that would leverage and complement each other's special assets. Our 38 strategically- chosen partners include 12 Tufts University schools/research centers, ten Tufts hospitals, three academic institutions (Brandeis University, Northeastern University, RAND Corporation), eight community-based organizations, and five industry partners, an outstanding and synergistic resources, opportunities, and education across the T1-T4 spectrum. Described in our application's four sections are four aims that build on this platform:
AIM 1 : Strengthen Tufls CTSI overall by;1) organizing and leading its partners in their commitment to this shared home for CTR;2) expanding efficient access for ail partners to a full spectrum of high-quality resources in a way that promotes collaborative CTR across disciplines and institutions;3) advancing the field of CTR through local and national leadership and development of novel methods;4) providing innovative and targeted education and training across the T1-4 spectrum. (Section I) AIM 2: Operationalize and implement the CTR home and its infra- stnjcture, sen/ices and programs, including Its central office personnel, administrative and financial management systems, committees, and other necessary structures. (Section II) AIM 3: Sustain and grow innovative resources, services, and policies that support and promote collaborative, cross-disciplinary, full-spectrum translational research. (Section III) AIM 4:Develop and broaden the CTR workforce through education and training across the T1-T4 spectrum, with a specific focus on addressing translational gaps between bench to bedside and from bedside to widespread impact on health. (Section IV)

Public Health Relevance

(See Instructions): Tufts Clinical and Translational Science Institute uses the entire spectrum of clinical and translational research (CTR) to help meet the promise and the public's needs of biomedical science.This includes bench to bedside (""""""""Tl"""""""") translation and crucially for having health impact, translation into effective clinical practice (""""""""T2""""""""), care delivery and public health (""""""""TS""""""""), and health policy ('74"""""""").

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Mentored Career Development Award (KL2)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S2))
Program Officer
Wilde, David B
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Tufts University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Ladin, Keren; Hanto, Douglas W (2017) Are geographic differences in transplantation inherently wrong? Curr Opin Organ Transplant 22:174-178
Ling, Qi; Xu, Xiao; Ye, Panpan et al. (2017) The prognostic relevance of primary tumor location in patients undergoing resection for pancreatic ductal adenocarcinoma. Oncotarget 8:15159-15167
Nevers, Tania; Salvador, Ane M; Velazquez, Francisco et al. (2017) Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure. J Exp Med 214:3311-3329
Linder, Deborah E; Siebens, Hannah C; Mueller, Megan K et al. (2017) Animal-assisted interventions: A national survey of health and safety policies in hospitals, eldercare facilities, and therapy animal organizations. Am J Infect Control 45:883-887
Pack, Quinn R; Priya, Aruna; Lagu, Tara C et al. (2017) Smoking Cessation Pharmacotherapy Among Smokers Hospitalized for Coronary Heart Disease. JAMA Intern Med 177:1525-1527
Miwa, Saki; Visintainer, Paul; Engelman, Richard et al. (2017) Effects of an Ambulation Orderly Program Among Cardiac Surgery Patients. Am J Med 130:1306-1312
Riley, Hayden; Headley, Samuel; Winter, Christa et al. (2017) Effect of Smoking Status on Exercise Perception and Intentions for Cardiac Rehabilitation Enrollment Among Patients Hospitalized With an Acute Cardiac Condition. J Cardiopulm Rehabil Prev :
Pack, Quinn R; Priya, Aruna; Lagu, Tara et al. (2016) Development and Validation of a Predictive Model for Short- and Medium-Term Hospital Readmission Following Heart Valve Surgery. J Am Heart Assoc 5:
Pack, Quinn R; Lahr, Brian D; Squires, Ray W et al. (2016) Survey Reported Participation in Cardiac Rehabilitation and Survival After Mitral or Aortic Valve Surgery. Am J Cardiol 117:1985-91
Salvador, Ane M; Nevers, Tania; Velázquez, Francisco et al. (2016) Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload-Induced Heart Failure. J Am Heart Assoc 5:e003126

Showing the most recent 10 out of 16 publications